EGF receptor signalling: the importance of presentation

Activation of the Drosophila EGF receptor requires the transmembrane TGF-alpha-like ligand Spitz. Recent studies have shed new light on the role of two transmembrane proteins, Star and Rhomboid, in the presentation and subsequent proteolytic processing of Spitz.

Saved in:
Bibliographic Details
Published in:Current biology 2000-05, Vol.10 (10), p.R388-R391
Main Author: Klaembt, C
Format: Article
Language:English
Subjects:
Animals
Drosophila
Drosophila - genetics
Drosophila - metabolism
Drosophila Proteins
Epidermal Growth Factor
ErbB Receptors - genetics
ErbB Receptors - metabolism
Membrane Proteins - genetics
Membrane Proteins - metabolism
Phosphoproteins - genetics
Phosphoproteins - metabolism
Rhomboid protein
Signal Transduction
signalling proteins
Spitz protein
Star protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Activation of the Drosophila EGF receptor requires the transmembrane TGF-alpha-like ligand Spitz. Recent studies have shed new light on the role of two transmembrane proteins, Star and Rhomboid, in the presentation and subsequent proteolytic processing of Spitz.
ISSN:0960-9822
DOI:10.1016/S0960-9822(00)00485-1