Comparison of the heparin coated vs the uncoated Jostent®—no influence on restenosis or clinical outcome

• Published in: European heart journal 2001-10, Vol.22 (19), p.1808-1816
• Main Authors: Wöhrle, J, Al-Khayer, E, Grötzinger, U, Schindler, C, Kochs, M, Hombach, V, Höher, M
• Format: Article
• Language: English
• Subjects: Anticoagulants - therapeutic use; Chi-Square Distribution; Coated Materials, Biocompatible; Coronary Angiography; Coronary Disease - therapy; Equipment Design; Female; Heparin - therapeutic use; heparin coating; Humans; Logistic Models; Male; Recurrence; Reoperation; restenosis; Risk Factors; Statistics, Nonparametric; Stent; Stents; thrombosis; Thrombosis - prevention & control; Treatment Outcome
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1053/euhj.2001.2608

Aims Heparin coating of stents is thought to reduce stent thrombosis and restenosis rates. However, clinical data comparing coated and uncoated stents of the same model are lacking. We compared the heparin coated (C) and the uncoated (U) version of the Jostent®stent with regard to the clinical and angiographic outcome after 6 months. Methods and Results Provisional stenting was done in 277 patients and 306 lesions; only 40 were Benestent-II like lesions. Delivery success rate was 98·4%. Both groups (C/U: n=156/150 lesions) were comparable in clinical and procedural data. Post stenting, reference diameter (C/U: 2·68±0·56/2·66±0·53mm) and minimal lumen diameter did not differ (C/U: 2·48±0·47/2·48±0·52mm). During follow-up the rate of subacute stent thrombosis (C/U: 1·9%/1·3%) and myocardial infarction did not differ. Angiography at the 6-month follow-up (79·4%) revealed no difference in restenosis rate (C/U: 33·1%/30·3%). Risk factors for restenosis were a type B2/C lesion (P