Preparation and characterization of solid lipid nanospheres containing paclitaxel

The study describes the development of stealth and non-stealth solid lipid nanospheres (SLNs) as colloidal carriers for paclitaxel, a drug with very low solubility. SLNs are constituted mainly of bioacceptable and biodegradable lipids, such as tripalmitin and phosphatidylcholine, and can incorporate...

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 2000-06, Vol.10 (4), p.305-309
Main Authors: Cavalli, Roberta, Caputo, Otto, Gasco, Maria Rosa
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemistry
Biological and medical sciences
Chemistry, Pharmaceutical
Colloidal carriers
Drug Carriers
DSC
General aspects
General pharmacology
Half-Life
Medical sciences
Paclitaxel
Paclitaxel - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phosphatidylcholines - chemical synthesis
Solid lipid nanospheres
Triglycerides - chemical synthesis
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Summary:The study describes the development of stealth and non-stealth solid lipid nanospheres (SLNs) as colloidal carriers for paclitaxel, a drug with very low solubility. SLNs are constituted mainly of bioacceptable and biodegradable lipids, such as tripalmitin and phosphatidylcholine, and can incorporate amounts of paclitaxel up to 2.8%. Stealth and non-stealth loaded SLNs are in the nanometer size range and can be sterilized and freeze-dried. Thermal analysis (differential scanning calorimetry) showed that paclitaxel is not able to crystallize in the SLNs. Release of paclitaxel from SLNs is very low. Non-stealth and stealth SLNs are stable over time without precipitation of paclitaxel and can be proposed for its parenteral administration.
ISSN:0928-0987
1879-0720
DOI:10.1016/S0928-0987(00)00081-6