Integrating centrosome structure with protein composition and function in animal cells

The centrosome found in animal cells is a complex and dynamic organelle that functions as the major microtubule organizing center. Structural studies over the past several decades have defined the primary structural features of the centrosome but recent studies are now beginning to reveal structural...

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Bibliographic Details
Published in:Microscopy research and technique 2000-06, Vol.49 (5), p.409-419
Main Authors: Mack, Gary J., Ou, Yongchun, Rattner, J.B.
Format: Article
Language:English
Subjects:
Animals
Autoantigens - analysis
Cell Cycle
Cell Cycle Proteins
Cells - cytology
centrioles
Centrioles - chemistry
Centrioles - ultrastructure
centrosome
Centrosome - chemistry
Centrosome - ultrastructure
Fluorescent Antibody Technique
Mammals
Microtubules - chemistry
Microtubules - ultrastructure
MTOCs
Proteins - analysis
Proteins - chemistry
Proteins - physiology
Spindle Apparatus - ultrastructure
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Summary:The centrosome found in animal cells is a complex and dynamic organelle that functions as the major microtubule organizing center. Structural studies over the past several decades have defined the primary structural features of the centrosome but recent studies are now beginning to reveal structural detail previously unknown. Concurrent with these studies has been an explosion in the identification of the proteins that reside within the centrosome. Our growing understanding of how protein composition integrates with centrosome structure and hence with function is the focus of this review. Microsc. Res. Tech. 49:409–419, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:1059-910X
1097-0029
DOI:10.1002/(SICI)1097-0029(20000601)49:5<409::AID-JEMT2>3.0.CO;2-V