Loading…

Diffusion tensor trace mapping in normal adult brain using single-shot epi technique. A methodological study of the aging brain

To quantify age-related changes of the average diffusion coefficient value in normal adult brain using orientation-independent diffusion tensor trace mapping and to address the methodological influences on diffusion quantification. Fifty-four normal subjects (aged 20-79 years) were studied on a 1.5-...

Full description

Saved in:
Bibliographic Details
Published in:Acta radiologica (1987) 2001-09, Vol.42 (5), p.447-458
Main Authors: CHEN, Z. G, LI, T.-Q, HINDMARSH, T
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To quantify age-related changes of the average diffusion coefficient value in normal adult brain using orientation-independent diffusion tensor trace mapping and to address the methodological influences on diffusion quantification. Fifty-four normal subjects (aged 20-79 years) were studied on a 1.5-T whole-body MR medical unit using a diffusion-weighted single-shot echo-planar imaging technique. Orientation-independent diffusion tensor trace maps were constructed for each subject using diffusion-weighted MR measurements in four different directions using a tetrahedral gradient combination pattern. The global average (including cerebral spinal fluid) and the tissue average of diffusion coefficients in adult brains were determined by analyzing the diffusion coefficient distribution histogram for the entire brain. Methodological influences on the measured diffusion coefficient were also investigated by comparing the results obtained using different experimental settings. Both global and tissue averages of the diffusion coefficient are significantly correlated with age (p
ISSN:0284-1851
1600-0455
DOI:10.1034/j.1600-0455.2001.420504.x