Incidence of hepatitis virus infection and severe liver dysfunction in patients receiving chemotherapy for hematologic malignancies

: Hepatitis virus infection through virus reactivation has a high risk of mortality in patients with hematological malignancies receiving chemotherapy. We examined the incidence of both hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and severe liver dysfunction (alanine aminotransfera...

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Bibliographic Details
Published in:European journal of haematology 2001-07, Vol.67 (1), p.45-50
Main Authors: Kawatani, Toshio, Suou, Takeaki, Tajima, Fumihito, Ishiga, Kiyomi, Omura, Hiromi, Endo, Akira, Ohmura, Hiroshi, Ikuta, Yujiro, Idobe, Youko, Kawasaki, Hironaka
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biological and medical sciences
DNA, Viral - blood
Drug toxicity and drugs side effects treatment
Female
Hematologic Neoplasms - complications
Hematologic Neoplasms - drug therapy
hematological malignancy
Hepacivirus - drug effects
Hepacivirus - physiology
Hepatitis B - complications
Hepatitis B - epidemiology
Hepatitis B - physiopathology
Hepatitis B - transmission
Hepatitis B Surface Antigens - blood
hepatitis B virus
Hepatitis B virus - drug effects
Hepatitis B virus - physiology
Hepatitis C - complications
Hepatitis C - epidemiology
Hepatitis C - physiopathology
hepatitis C virus
Human viral diseases
Humans
Incidence
Infectious diseases
Japan - epidemiology
Liver - physiopathology
Liver Failure - etiology
Liver Function Tests
Male
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Polymerase Chain Reaction
severe liver dysfunction
Transfusion Reaction
Viral diseases
Viral hepatitis
Virus Activation - drug effects
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Summary:: Hepatitis virus infection through virus reactivation has a high risk of mortality in patients with hematological malignancies receiving chemotherapy. We examined the incidence of both hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and severe liver dysfunction (alanine aminotransferase >ten times the normal upper limit and total bilirubin >5 mg/dl) during chemotherapy in 268 patients with hematological malignancies. Eight patients (3.0%) were infected with HBV and 22 patients (8.2%) were infected with HCV. One patient (0.4%) was infected with both HBV and HCV. HBV‐ or HCV‐infected patients showed severe liver dysfunction at a significantly higher incidence than non‐infected patients (11/31 (35.5%) vs. 0/237 (0%), p
ISSN:0902-4441
1600-0609
DOI:10.1034/j.1600-0609.2001.067001045.x