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Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy
Deficiency of folate during pregnancy is associated with megaloblastic anaemia. Lower levels of folate and vitamin B12 have been reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid levels are a sensitive indicator of mild vitamin...
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Published in: | Clinical and laboratory haematology 2001-06, Vol.23 (3), p.161-165 |
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creator | Mcmullin, M.F. Young, P.B. Bailie, K.E.M. Savage, G.A. Lappin, T.R.J. White, R. |
description | Deficiency of folate during pregnancy is associated with megaloblastic anaemia. Lower levels of folate and vitamin B12 have been reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We have investigated the relationship between serum concentration of total homocysteine, methylmalonic acid, vitamin B12 and folate in pregnancy. A significant inverse correlation was found between homocysteine and red cell folate and, to a lesser extent, serum folate. In addition, a significant inverse correlation was found between methylmalonic acid and vitamin B12. No significant relationship was found between homocysteine and vitamin B12. The relationship between red cell folate and serum folate and homocysteine may be useful for detecting borderline folate deficiency in pregnancy and indicate pregnancies at risk of neural tube defect. These sensitive assays are useful tools for the further investigation of folate vitamin B12 and metabolism in normal and abnormal pregnancy. |
doi_str_mv | 10.1046/j.1365-2257.2001.00370.x |
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Lower levels of folate and vitamin B12 have been reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We have investigated the relationship between serum concentration of total homocysteine, methylmalonic acid, vitamin B12 and folate in pregnancy. A significant inverse correlation was found between homocysteine and red cell folate and, to a lesser extent, serum folate. In addition, a significant inverse correlation was found between methylmalonic acid and vitamin B12. No significant relationship was found between homocysteine and vitamin B12. The relationship between red cell folate and serum folate and homocysteine may be useful for detecting borderline folate deficiency in pregnancy and indicate pregnancies at risk of neural tube defect. These sensitive assays are useful tools for the further investigation of folate vitamin B12 and metabolism in normal and abnormal pregnancy.</description><identifier>ISSN: 0141-9854</identifier><identifier>EISSN: 1365-2257</identifier><identifier>DOI: 10.1046/j.1365-2257.2001.00370.x</identifier><identifier>PMID: 11553056</identifier><identifier>CODEN: CLHAD3</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adult ; Biological and medical sciences ; Biomarkers - blood ; Female ; folate ; Folic Acid Deficiency - blood ; Folic Acid Deficiency - diagnosis ; Gynecology. Andrology. Obstetrics ; Hematology ; Homocysteine ; Homocysteine - blood ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Management. Prenatal diagnosis ; Medical sciences ; methylmalonic acid ; Methylmalonic Acid - blood ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy. Fetus. Placenta ; Vitamin B 12 Deficiency - blood ; Vitamin B 12 Deficiency - diagnosis ; vitamin B12</subject><ispartof>Clinical and laboratory haematology, 2001-06, Vol.23 (3), p.161-165</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14107082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11553056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mcmullin, M.F.</creatorcontrib><creatorcontrib>Young, P.B.</creatorcontrib><creatorcontrib>Bailie, K.E.M.</creatorcontrib><creatorcontrib>Savage, G.A.</creatorcontrib><creatorcontrib>Lappin, T.R.J.</creatorcontrib><creatorcontrib>White, R.</creatorcontrib><title>Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy</title><title>Clinical and laboratory haematology</title><addtitle>Clin Lab Haematol</addtitle><description>Deficiency of folate during pregnancy is associated with megaloblastic anaemia. Lower levels of folate and vitamin B12 have been reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We have investigated the relationship between serum concentration of total homocysteine, methylmalonic acid, vitamin B12 and folate in pregnancy. A significant inverse correlation was found between homocysteine and red cell folate and, to a lesser extent, serum folate. In addition, a significant inverse correlation was found between methylmalonic acid and vitamin B12. No significant relationship was found between homocysteine and vitamin B12. The relationship between red cell folate and serum folate and homocysteine may be useful for detecting borderline folate deficiency in pregnancy and indicate pregnancies at risk of neural tube defect. These sensitive assays are useful tools for the further investigation of folate vitamin B12 and metabolism in normal and abnormal pregnancy.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Female</subject><subject>folate</subject><subject>Folic Acid Deficiency - blood</subject><subject>Folic Acid Deficiency - diagnosis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hematology</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>methylmalonic acid</subject><subject>Methylmalonic Acid - blood</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - blood</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Vitamin B 12 Deficiency - blood</subject><subject>Vitamin B 12 Deficiency - diagnosis</subject><subject>vitamin B12</subject><issn>0141-9854</issn><issn>1365-2257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpFkU1vEzEQhi0EomngLyBf4LaLx5_ZAweooGkV0R6KerQmXhsc9iOsN5D993VI2p5sa553NOOHEAqsBCb1x00JQquCc2VKzhiUjAnDyv0LMnsqvCQzBhKKaqHkGTlPaZNBAca8JmcASgmm9Iy4Zd_2bkqjj52n2NW09eOvqWmx6bvoKLpYU0w0dnV0OPZDon2goW9wPOJ_44ht7OgX4LT2IbroOzdlnm4H_7PD_HhDXgVskn97Oufkx7evdxfLYnVzeXXxeVVELiUrDId6XQunHWcujy5Y8FUdZCUEVAtpQARcI8d1JSsjeHBKa15pI4URRi6EmJMPx77bof-z82m0bUzONw12vt8lawC0hkzOybsTuFu3vrbbIbY4TPbxWzLw_gRgctiEIa8R0zMngRm24Jn7dOT-xcZPz3VmD5rsxh5s2IMNe9Bk_2uye3t1vVrmW84Xx3zMAvZPeRx-W52XUvb--6W9FXeSqftVbvYAgoOTKA</recordid><startdate>200106</startdate><enddate>200106</enddate><creator>Mcmullin, M.F.</creator><creator>Young, P.B.</creator><creator>Bailie, K.E.M.</creator><creator>Savage, G.A.</creator><creator>Lappin, T.R.J.</creator><creator>White, R.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200106</creationdate><title>Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy</title><author>Mcmullin, M.F. ; Young, P.B. ; Bailie, K.E.M. ; Savage, G.A. ; Lappin, T.R.J. ; White, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2440-721dbd3c6c20c01430fe9df49331984713faba2ab949732fc5662967437374833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Female</topic><topic>folate</topic><topic>Folic Acid Deficiency - blood</topic><topic>Folic Acid Deficiency - diagnosis</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematology</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>methylmalonic acid</topic><topic>Methylmalonic Acid - blood</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - blood</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Vitamin B 12 Deficiency - blood</topic><topic>Vitamin B 12 Deficiency - diagnosis</topic><topic>vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mcmullin, M.F.</creatorcontrib><creatorcontrib>Young, P.B.</creatorcontrib><creatorcontrib>Bailie, K.E.M.</creatorcontrib><creatorcontrib>Savage, G.A.</creatorcontrib><creatorcontrib>Lappin, T.R.J.</creatorcontrib><creatorcontrib>White, R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and laboratory haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mcmullin, M.F.</au><au>Young, P.B.</au><au>Bailie, K.E.M.</au><au>Savage, G.A.</au><au>Lappin, T.R.J.</au><au>White, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy</atitle><jtitle>Clinical and laboratory haematology</jtitle><addtitle>Clin Lab Haematol</addtitle><date>2001-06</date><risdate>2001</risdate><volume>23</volume><issue>3</issue><spage>161</spage><epage>165</epage><pages>161-165</pages><issn>0141-9854</issn><eissn>1365-2257</eissn><coden>CLHAD3</coden><abstract>Deficiency of folate during pregnancy is associated with megaloblastic anaemia. Lower levels of folate and vitamin B12 have been reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We have investigated the relationship between serum concentration of total homocysteine, methylmalonic acid, vitamin B12 and folate in pregnancy. A significant inverse correlation was found between homocysteine and red cell folate and, to a lesser extent, serum folate. In addition, a significant inverse correlation was found between methylmalonic acid and vitamin B12. No significant relationship was found between homocysteine and vitamin B12. The relationship between red cell folate and serum folate and homocysteine may be useful for detecting borderline folate deficiency in pregnancy and indicate pregnancies at risk of neural tube defect. These sensitive assays are useful tools for the further investigation of folate vitamin B12 and metabolism in normal and abnormal pregnancy.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>11553056</pmid><doi>10.1046/j.1365-2257.2001.00370.x</doi><tpages>5</tpages></addata></record> |
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subjects | Adult Biological and medical sciences Biomarkers - blood Female folate Folic Acid Deficiency - blood Folic Acid Deficiency - diagnosis Gynecology. Andrology. Obstetrics Hematology Homocysteine Homocysteine - blood Humans Investigative techniques, diagnostic techniques (general aspects) Management. Prenatal diagnosis Medical sciences methylmalonic acid Methylmalonic Acid - blood Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pregnancy Pregnancy Complications - blood Pregnancy. Fetus. Placenta Vitamin B 12 Deficiency - blood Vitamin B 12 Deficiency - diagnosis vitamin B12 |
title | Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy |
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