Leishmania major infections in Phlebotomus duboscqi fed on murine models immunized with L. major subcellular antigens and sandfly gut antigens

The ability of antibodies in bloodmeals of mice and hamsters immunized with Leishmania major subcellular fractions and sandfly (Phlebotomus duboscqi) gut antigens to inhibit development of L. major in its vector P. duboscqi was examined. Antibodies from animals immunized with either L. major subcell...

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Bibliographic Details
Published in:Onderstepoort journal of veterinary research 2000-03, Vol.67 (1), p.57-63
Main Authors: Mbati, P A, Anjili, C O, Odongo, S, Ogaja, P, Tonui, W
Format: Article
Language:English
Subjects:
Animals
Antigens, Protozoan - administration & dosage
Antigens, Protozoan - immunology
Cricetinae - immunology
Female
Guinea Pigs - immunology
Host-Parasite Interactions
Immunization - veterinary
Immunologic Tests
Infection Control
Insect Control - methods
Leishmania major - immunology
Leishmaniasis - etiology
Leishmaniasis - prevention & control
Leishmaniasis - transmission
Mice - immunology
Psychodidae - immunology
Subcellular Fractions
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Summary:The ability of antibodies in bloodmeals of mice and hamsters immunized with Leishmania major subcellular fractions and sandfly (Phlebotomus duboscqi) gut antigens to inhibit development of L. major in its vector P. duboscqi was examined. Antibodies from animals immunized with either L. major subcellular fractions alone or sandfly gut antigen alone were not very effective in inhibiting development of L. major in the sandfly. When P. duboscqi were fed on blood from animals immunized with both parasite flagella and sandfly gut antigen, development of L. major was significantly inhibited (P
ISSN:0030-2465