Association of human parvovirus B19 infection with acute meningoencephalitis

To find out the incidence and clinical presentation of parvovirus B19 meningoencephalitis, we tested samples of cerebrospinal fluid from 162 patients (one from each patient) with undiagnosed meningoencephalitis, who presented between March, 1997, and March, 1998 (an outbreak period) using nested PCR...

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Bibliographic Details
Published in:The Lancet (British edition) 2001-09, Vol.358 (9283), p.729-730
Main Authors: Barah, Faraj, Vallely, Pamela J, Chiswick, Malcolm L, Cleator, Graham M, Kerr, Jonathan R
Format: Article
Language:English
Subjects:
Abnormalities
Adolescent
Anemia
Ataxia
Biological and medical sciences
Brain
Cerebrospinal fluid
Child
Child, Preschool
Congenital diseases
Cytomegalovirus
Deoxyribonucleic acid
Disease Outbreaks
Distilled water
DNA
Encephalitis
Female
Genes
Hepatitis
Human viral diseases
Humans
Immunoglobulins
Incidence
Infant
Infant, Newborn
Infections
Infectious diseases
Lung diseases
Magnesium
Male
Medical sciences
Meningitis
Meningoencephalitis
Meningoencephalitis - epidemiology
Meningoencephalitis - physiopathology
Meningoencephalitis - virology
Neurological complications
Outbreaks
Parvoviridae Infections - cerebrospinal fluid
Parvoviridae Infections - epidemiology
Parvoviridae Infections - physiopathology
Parvovirus B19, Human - genetics
Parvovirus B19, Human - isolation & purification
Parvoviruses
Patients
Polymerase Chain Reaction
Public health
Studies
Surfactants
Turner's syndrome
United Kingdom - epidemiology
Viral diseases
Viral diseases of the nervous system
Viruses
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Summary:To find out the incidence and clinical presentation of parvovirus B19 meningoencephalitis, we tested samples of cerebrospinal fluid from 162 patients (one from each patient) with undiagnosed meningoencephalitis, who presented between March, 1997, and March, 1998 (an outbreak period) using nested PCR for B19 genes. Seven patients were positive; an incidence of 4·3%. Five additional cases of meningoencephalitis were detected from other years. Three patients with underlying disorders (haemophagocytic lymphohistiocytosis, Cockayne's syndrome, and Turner's syndrome) died. Neurological sequelae were observed in three surviving patients, all of whom had had striking abnormalities detected on brain scans done during the acute phase.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(01)05905-0