Liposome-delivered angiostatin strongly inhibits tumor growth and metastatization in a transgenic model of spontaneous breast cancer

The possibility to inhibit tumor growth by interfering with the formation of new vessels, which most neoplasias depend on, has recently raised considerable interest. An angiogenic switch, in which proliferating cells acquire the ability to direct new vessel formation, is thought to be an early step...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2000-05, Vol.60 (10), p.2660-2665
Main Authors: SACCO, M. G, CANIATTI, M, CATO, E. M, FRATTINI, A, CHIESA, G, CERUTI, R, ADORNI, F, ZECCA, L, SCANZIANI, E, VEZZONI, P
Format: Article
Language:English
Subjects:
angiostatin
Angiostatins
Animal tumors. Experimental tumors
Animals
Antineoplastic agents
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Chemotherapy
Female
Genetic Therapy
Humans
Liposomes
Mammary Neoplasms, Experimental - drug therapy
Mammary Neoplasms, Experimental - pathology
Medical sciences
Membrane Proteins - genetics
Mice
Mice, Transgenic
Neoplasm Metastasis - prevention & control
Peptide Fragments - administration & dosage
Peptide Fragments - therapeutic use
Pharmacology. Drug treatments
Plasminogen - administration & dosage
Plasminogen - therapeutic use
Receptor, ErbB-2 - genetics
Receptors, Virus - genetics
Spontaneous animal tumors
Tumors
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Summary:The possibility to inhibit tumor growth by interfering with the formation of new vessels, which most neoplasias depend on, has recently raised considerable interest. An angiogenic switch, in which proliferating cells acquire the ability to direct new vessel formation, is thought to be an early step in the natural history of solid tumors. Using a transgenic model of breast cancer, which shows many similarities to its human counterpart, including ability to metastasize, we targeted angiostatin production to an early stage of tumor formation. Liposome-delivered angiostatin considerably delayed primary tumor growth and, more importantly, inhibited the appearance of lung metastases. These findings can be relevant to the design of therapeutic intervention in humans.
ISSN:0008-5472
1538-7445