Phospholipid composition of high-density lipoproteins reflects lipolysis of triglyceride-rich lipoproteins during hyperlipidemia

We studied phospholipid composition of high-density lipoproteins in patients with normo- and hypertriglyceridemia treated with various hypolipidemic preparations (simvastatin and fenofibrate). Both preparations changed phospholipid composition of high-density lipoproteins and improved their function...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2001-04, Vol.131 (4), p.321-324
Main Authors: Perova, N V, Ozerova, I N, Paramonova, I V, Olfer'ev, A M, Akhmedzhanov, N M, Pavlova, L I, Oganov, R G
Format: Article
Language:English
Subjects:
Adult
Anticholesteremic Agents - pharmacology
Cardiolipins - blood
Cholesterol - blood
Cholesterol, HDL - blood
Fenofibrate - pharmacology
Humans
Hyperlipidemias - blood
Hypolipidemic Agents - pharmacology
Lipolysis
Lipoproteins, HDL - blood
Lysophosphatidylcholines - blood
Male
Middle Aged
Phosphatidylcholines - blood
Phosphatidylethanolamines - blood
Phospholipids - blood
Simvastatin - pharmacology
Sphingomyelins - blood
Triglycerides - blood
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Summary:We studied phospholipid composition of high-density lipoproteins in patients with normo- and hypertriglyceridemia treated with various hypolipidemic preparations (simvastatin and fenofibrate). Both preparations changed phospholipid composition of high-density lipoproteins and improved their functional activity. The differences in the phospholipid composition of high-density lipoproteins were probably related to lipolysis of triglyceride-rich lipoproteins catalyzed by lipoprotein lipase and, in particular, hepatic lipase.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1017983615183