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INFLAMMATORY AND IMMUNOLOGICAL PARAMETERS IN CHILDREN WITH HAEMOLYTIC UREMIC SYNDROME (HUS) AND GASTROENTERITIS—PATHOPHYSIOLOGICAL AND DIAGNOSTIC CLUES
The objective of this study was to identify parameters indicating a risk for developing typical haemolytic uremic syndrome (D+HUS) during the prodromal phase of diarrhea caused by enterohaemorrhagic Escherichia coli (EHEC). Forty-eight children were studied prospectively with regard to inflammatory...
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| Published in: | Cytokine (Philadelphia, Pa.) Pa.), 2000-06, Vol.12 (6), p.822-827 |
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| cited_by | cdi_FETCH-LOGICAL-c342t-46a17fa1d913073fdef09c41318b515eece1269f779cd6f70570c7d0bc057ba53 |
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| cites | cdi_FETCH-LOGICAL-c342t-46a17fa1d913073fdef09c41318b515eece1269f779cd6f70570c7d0bc057ba53 |
| container_end_page | 827 |
| container_issue | 6 |
| container_start_page | 822 |
| container_title | Cytokine (Philadelphia, Pa.) |
| container_volume | 12 |
| creator | Westerholt, Sören Hartung, Thomas Tollens, Martin Güstrau, Andrea Oberhoffer, Mathias Karch, Helge Klare, Bernd Pfeffer, Klaus Emmrich, Peter Oberhoffer, Renate |
| description | The objective of this study was to identify parameters indicating a risk for developing typical haemolytic uremic syndrome (D+HUS) during the prodromal phase of diarrhea caused by enterohaemorrhagic Escherichia coli (EHEC). Forty-eight children were studied prospectively with regard to inflammatory serum factors on admission to hospital. Ten patients developed D+HUS (group I), 15 suffered from viral-gastroenteritis (group IIa) and 23 from other types of bacterial gastroenteritis (group IIb). Mean levels of IL-8 tended to be elevated in group I compared to groups IIa and IIb. Neopterin and IL-10 levels particularly were significantly decreased in HUS in comparison to both gastroenteritis groups. Low IL-10 levels indicate a substantial disregulation of the immune response in HUS, as IL-10 downregulates the pro-inflammatory response and suppresses pro-coagulant activity in experimental endotoxemia. Our results suggest low neopterin, high IL-8 and especially low IL-10 levels are indicators of a high risk for developing HUS. |
| doi_str_mv | 10.1006/cyto.1999.0624 |
| format | article |
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Forty-eight children were studied prospectively with regard to inflammatory serum factors on admission to hospital. Ten patients developed D+HUS (group I), 15 suffered from viral-gastroenteritis (group IIa) and 23 from other types of bacterial gastroenteritis (group IIb). Mean levels of IL-8 tended to be elevated in group I compared to groups IIa and IIb. Neopterin and IL-10 levels particularly were significantly decreased in HUS in comparison to both gastroenteritis groups. Low IL-10 levels indicate a substantial disregulation of the immune response in HUS, as IL-10 downregulates the pro-inflammatory response and suppresses pro-coagulant activity in experimental endotoxemia. Our results suggest low neopterin, high IL-8 and especially low IL-10 levels are indicators of a high risk for developing HUS.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1006/cyto.1999.0624</identifier><identifier>PMID: 10843773</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Bacterial Infections - complications ; Biomarkers - blood ; C-Reactive Protein - analysis ; Child ; Child, Preschool ; Cytokines - blood ; Gastroenteritis - blood ; Gastroenteritis - diagnosis ; Gastroenteritis - immunology ; Gastroenteritis - physiopathology ; haemolytic uremic syndrome/interleukin-10/interleukin 8/neopterin/enterohaemorrhagic E. coli ; Hemolytic-Uremic Syndrome - blood ; Hemolytic-Uremic Syndrome - diagnosis ; Hemolytic-Uremic Syndrome - immunology ; Hemolytic-Uremic Syndrome - physiopathology ; Humans ; Inflammation ; Interleukin-10 - blood ; Interleukin-6 - blood ; Interleukin-8 - blood ; Reference Values ; Risk Factors ; Tumor Necrosis Factor-alpha - analysis ; Virus Diseases - complications</subject><ispartof>Cytokine (Philadelphia, Pa.), 2000-06, Vol.12 (6), p.822-827</ispartof><rights>2000 Academic Press</rights><rights>Copyright 2000 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-46a17fa1d913073fdef09c41318b515eece1269f779cd6f70570c7d0bc057ba53</citedby><cites>FETCH-LOGICAL-c342t-46a17fa1d913073fdef09c41318b515eece1269f779cd6f70570c7d0bc057ba53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10843773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westerholt, Sören</creatorcontrib><creatorcontrib>Hartung, Thomas</creatorcontrib><creatorcontrib>Tollens, Martin</creatorcontrib><creatorcontrib>Güstrau, Andrea</creatorcontrib><creatorcontrib>Oberhoffer, Mathias</creatorcontrib><creatorcontrib>Karch, Helge</creatorcontrib><creatorcontrib>Klare, Bernd</creatorcontrib><creatorcontrib>Pfeffer, Klaus</creatorcontrib><creatorcontrib>Emmrich, Peter</creatorcontrib><creatorcontrib>Oberhoffer, Renate</creatorcontrib><title>INFLAMMATORY AND IMMUNOLOGICAL PARAMETERS IN CHILDREN WITH HAEMOLYTIC UREMIC SYNDROME (HUS) AND GASTROENTERITIS—PATHOPHYSIOLOGICAL AND DIAGNOSTIC CLUES</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>The objective of this study was to identify parameters indicating a risk for developing typical haemolytic uremic syndrome (D+HUS) during the prodromal phase of diarrhea caused by enterohaemorrhagic Escherichia coli (EHEC). 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Our results suggest low neopterin, high IL-8 and especially low IL-10 levels are indicators of a high risk for developing HUS.</description><subject>Bacterial Infections - complications</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytokines - blood</subject><subject>Gastroenteritis - blood</subject><subject>Gastroenteritis - diagnosis</subject><subject>Gastroenteritis - immunology</subject><subject>Gastroenteritis - physiopathology</subject><subject>haemolytic uremic syndrome/interleukin-10/interleukin 8/neopterin/enterohaemorrhagic E. coli</subject><subject>Hemolytic-Uremic Syndrome - blood</subject><subject>Hemolytic-Uremic Syndrome - diagnosis</subject><subject>Hemolytic-Uremic Syndrome - immunology</subject><subject>Hemolytic-Uremic Syndrome - physiopathology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-8 - blood</subject><subject>Reference Values</subject><subject>Risk Factors</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Virus Diseases - complications</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp1kc2O0zAUhS0EYmYKW5bIK8QsWq7jNK6XVuppLOWnyo9QV1bqOFJQOxniFml2PAQbXo8nIaEVYsPqnsW539U9B6F3BBYEIPhknk_9gnDOFxB4_gt0S4AHcwCPvpy0T-d-EAQ36M65LwDAKWOv0Q2BlT8qeot-qvQhFkkiyizfYZGusUqSKs3ibKNCEeOtyEUiS5kXWKU4jFS8zmWKP6sywpGQSRbvShXiKpfJOIpdus6zROKPUVXc_8FtRFHmmUxHhCpV8ev7j60oo2wb7Qr198pkXCuxSbNiooVxJYs36FVbH5x9e50zVD3IMozm16W5ob53Gt-rCWtr0nBCgdG2sS1w4xNKVvslWVprLPEC3jLGTRO0DJYMDGtgb0a1r5d0hj5cuE9D__Vs3UkfO2fs4VA_2v7sNCOEeVOgM7S4GM3QOzfYVj8N3bEenjUBPZWhpzL0VIaeyhgX3l_J5_3RNv_YL-mPhtXFYMf_vnV20M509tHYphusOemm7_7H_g2Jl46j</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Westerholt, Sören</creator><creator>Hartung, Thomas</creator><creator>Tollens, Martin</creator><creator>Güstrau, Andrea</creator><creator>Oberhoffer, Mathias</creator><creator>Karch, Helge</creator><creator>Klare, Bernd</creator><creator>Pfeffer, Klaus</creator><creator>Emmrich, Peter</creator><creator>Oberhoffer, Renate</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>INFLAMMATORY AND IMMUNOLOGICAL PARAMETERS IN CHILDREN WITH HAEMOLYTIC UREMIC SYNDROME (HUS) AND GASTROENTERITIS—PATHOPHYSIOLOGICAL AND DIAGNOSTIC CLUES</title><author>Westerholt, Sören ; 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| fulltext | fulltext |
| identifier | ISSN: 1043-4666 |
| ispartof | Cytokine (Philadelphia, Pa.), 2000-06, Vol.12 (6), p.822-827 |
| issn | 1043-4666 1096-0023 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Bacterial Infections - complications Biomarkers - blood C-Reactive Protein - analysis Child Child, Preschool Cytokines - blood Gastroenteritis - blood Gastroenteritis - diagnosis Gastroenteritis - immunology Gastroenteritis - physiopathology haemolytic uremic syndrome/interleukin-10/interleukin 8/neopterin/enterohaemorrhagic E. coli Hemolytic-Uremic Syndrome - blood Hemolytic-Uremic Syndrome - diagnosis Hemolytic-Uremic Syndrome - immunology Hemolytic-Uremic Syndrome - physiopathology Humans Inflammation Interleukin-10 - blood Interleukin-6 - blood Interleukin-8 - blood Reference Values Risk Factors Tumor Necrosis Factor-alpha - analysis Virus Diseases - complications |
| title | INFLAMMATORY AND IMMUNOLOGICAL PARAMETERS IN CHILDREN WITH HAEMOLYTIC UREMIC SYNDROME (HUS) AND GASTROENTERITIS—PATHOPHYSIOLOGICAL AND DIAGNOSTIC CLUES |
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