SNF4435C and D, Novel Immunosuppressants Produced by a Strain of Streptomyces spectabilis: I. Taxonomy, Fermentation, Isolation and Biological Activities

SNF4435C and D, novel nitrophenyl pyrones, have been isolated from the culture broth of an actinomycete strain SNF4435. The strain was identified as Streptomyces spectabilis from its morphological and cultural characteristics. SNF4435C and D showed a potent immunosuppressive activity in vitro and se...

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Bibliographic Details
Published in:Journal of antibiotics 2001/07/25, Vol.54(7), pp.541-547
Main Authors: KUROSAWA, KAZUHIKO, TAKAHASHI, KOSAKU, TSUDA, EISUKE
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Division - drug effects
Dose-Response Relationship, Drug
Escherichia coli - drug effects
Fermentation
HL-60 Cells
Humans
Immunomodulators
Immunosuppressive Agents - isolation & purification
Immunosuppressive Agents - pharmacology
K562 Cells
KB Cells
Lymphocyte Activation - drug effects
Medical sciences
Mice
Microbial Sensitivity Tests
Nitro Compounds - isolation & purification
Nitro Compounds - pharmacology
Pharmacology. Drug treatments
Pyrones - isolation & purification
Pyrones - pharmacology
Salmonella typhimurium - drug effects
Streptomyces - chemistry
Streptomyces - classification
Streptomyces - metabolism
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Summary:SNF4435C and D, novel nitrophenyl pyrones, have been isolated from the culture broth of an actinomycete strain SNF4435. The strain was identified as Streptomyces spectabilis from its morphological and cultural characteristics. SNF4435C and D showed a potent immunosuppressive activity in vitro and selectively suppressed B-cell proliferation induced by LPS versus T-cell proliferation induced by Con A.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.54.541