How Do Observational Studies Expand the Evidence Base for Therapy?

When the results of observational studies and randomized trials are congruent in both direction and magnitude, the case for broader therapeutic effectiveness is strengthened. Sophisticated observational studies provide assurance that extending the results of the randomized trials of aspirin to unstu...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2001-09, Vol.286 (10), p.1228-1230
Main Authors: Radford, Martha J, Foody, JoAnne M
Format: Article
Language:English
Subjects:
Clinical trials
Cohort Studies
Drug therapy
Effectiveness
Evidence-Based Medicine
Humans
Observation
Randomized Controlled Trials as Topic
Studies
Citations: Items that cite this one
Online Access:Get full text
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Description
Summary:When the results of observational studies and randomized trials are congruent in both direction and magnitude, the case for broader therapeutic effectiveness is strengthened. Sophisticated observational studies provide assurance that extending the results of the randomized trials of aspirin to unstudied or understudied patient groups will provide benefit rather than harm.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.286.10.1228