Synthesis and Terminal Functionalization of a Polymerizable Phosphatidylethanolamine

We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(ε-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substra...

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Bibliographic Details
Published in:Bioconjugate chemistry 2001-09, Vol.12 (5), p.673-677
Main Authors: Sun, Xue-Long, Liu, Hongbo, Orban, Janine M, Sun, Lijun, Chaikof, Elliot L
Format: Article
Language:English
Subjects:
Acrylates - chemistry
Acrylic Resins - chemistry
Cross-Linking Reagents
Drug Design
Membranes, Artificial
Microspheres
Phosphatidylethanolamines - chemistry
Polymers - chemical synthesis
Polymers - chemistry
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Summary:We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(ε-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-situ photocopolymerization.
ISSN:1043-1802
1520-4812
DOI:10.1021/bc015502w