CHARACTERIZATION OF JOK-1, A HUMAN GASTRIC EPITHELIAL CELL LINE

Human gastric epithelial cells were isolated from samples of human gastric lining and immortalized with simian virus 40 (SV40) to generate the stable human gastric epithelial cell line “JOK-1.” These cells express conventional epithelial markers (vimentin, cytokeratin-18, occludin, N- and E-cadherin...

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Published in:In vitro cellular & developmental biology. Animal 2000-04, Vol.36 (4), p.228-234
Main Authors: OKAYAMA, N, FOWLER, M. R, JENNINGS, S. R, PATEL, P, SPECIAN, R, ALEXANDER, B, JACKSON, T. H, OSHIMA, T, SHANNON, K, ALEXANDER, J. S
Format: Article
Language:English
Subjects:
Antigens
Antigens, Polyomavirus Transforming - metabolism
beta Catenin
Blotting, Western
cadherin
Cadherins
Cadherins - metabolism
Cell Line, Transformed - cytology
Cell Line, Transformed - metabolism
Cell lines
CELLULAR MODELS
Cultured cells
cytokeratin
Cytoskeletal Proteins - metabolism
Epithelial cells
Epithelial Cells - cytology
Epithelial Cells - metabolism
Fluorescent Antibody Technique
Genetic Markers
Humans
Keratins - metabolism
Kidney - cytology
Membrane Proteins - metabolism
mucin
Mucins
Occludin
Phosphoproteins - metabolism
Simian virus 40
Simian virus 40 - genetics
Solutes
Stomach
Stomach - cytology
Trans-Activators
Transfection
Vimentin
Vimentin - metabolism
Zonula Occludens-1 Protein
Zonula Occludens-2 Protein
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container_end_page 234
container_issue 4
container_start_page 228
container_title In vitro cellular & developmental biology. Animal
container_volume 36
creator OKAYAMA, N
FOWLER, M. R
JENNINGS, S. R
PATEL, P
SPECIAN, R
ALEXANDER, B
JACKSON, T. H
OSHIMA, T
SHANNON, K
ALEXANDER, J. S
description Human gastric epithelial cells were isolated from samples of human gastric lining and immortalized with simian virus 40 (SV40) to generate the stable human gastric epithelial cell line “JOK-1.” These cells express conventional epithelial markers (vimentin, cytokeratin-18, occludin, N- and E-cadherins, β-catenin, ZO-1, ZO-2, mucin, epithelial specific antigen) as well as SV40 large T-antigen. These cells rapidly externalized E-cadherin in response to acidic medium, and exhibited epithelial-like barrier properties that are also regulated by media pH. In contrast, the kidney epithelial cell line “MDCK” also expresses several epithelial markers (vimentin, cytokeratin-18, occludin, N- and E-cadherin, β-catenin, ZO-1, ZO-2, epithelial specific antigen), but does not express mucin, or large T-antigen. However, MDCK rapidly internalize their E-cadherin from the cell surface and increase the solute flux in an acidic medium. These data suggest that the JOK-1 cell line is a potentially useful cell line for developing models of gastric epithelial function, development, and disease.
doi_str_mv 10.1290/1071-2690(2000)036<0228:COJAHG>2.0.CO;2
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R ; JENNINGS, S. R ; PATEL, P ; SPECIAN, R ; ALEXANDER, B ; JACKSON, T. H ; OSHIMA, T ; SHANNON, K ; ALEXANDER, J. S</creator><creatorcontrib>OKAYAMA, N ; FOWLER, M. R ; JENNINGS, S. R ; PATEL, P ; SPECIAN, R ; ALEXANDER, B ; JACKSON, T. H ; OSHIMA, T ; SHANNON, K ; ALEXANDER, J. S</creatorcontrib><description>Human gastric epithelial cells were isolated from samples of human gastric lining and immortalized with simian virus 40 (SV40) to generate the stable human gastric epithelial cell line “JOK-1.” These cells express conventional epithelial markers (vimentin, cytokeratin-18, occludin, N- and E-cadherins, β-catenin, ZO-1, ZO-2, mucin, epithelial specific antigen) as well as SV40 large T-antigen. These cells rapidly externalized E-cadherin in response to acidic medium, and exhibited epithelial-like barrier properties that are also regulated by media pH. In contrast, the kidney epithelial cell line “MDCK” also expresses several epithelial markers (vimentin, cytokeratin-18, occludin, N- and E-cadherin, β-catenin, ZO-1, ZO-2, epithelial specific antigen), but does not express mucin, or large T-antigen. However, MDCK rapidly internalize their E-cadherin from the cell surface and increase the solute flux in an acidic medium. 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subjects Antigens
Antigens, Polyomavirus Transforming - metabolism
beta Catenin
Blotting, Western
cadherin
Cadherins
Cadherins - metabolism
Cell Line, Transformed - cytology
Cell Line, Transformed - metabolism
Cell lines
CELLULAR MODELS
Cultured cells
cytokeratin
Cytoskeletal Proteins - metabolism
Epithelial cells
Epithelial Cells - cytology
Epithelial Cells - metabolism
Fluorescent Antibody Technique
Genetic Markers
Humans
Keratins - metabolism
Kidney - cytology
Membrane Proteins - metabolism
mucin
Mucins
Occludin
Phosphoproteins - metabolism
Simian virus 40
Simian virus 40 - genetics
Solutes
Stomach
Stomach - cytology
Trans-Activators
Transfection
Vimentin
Vimentin - metabolism
Zonula Occludens-1 Protein
Zonula Occludens-2 Protein
title CHARACTERIZATION OF JOK-1, A HUMAN GASTRIC EPITHELIAL CELL LINE
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