Gene polymorphisms and transplantation

The influence of gene polymorphisms in key immunoregulatory molecules on the clinical course post-transplant has become an area of active research, since it offers a possible explanation for the heterogeneity in outcomes between individuals. Several groups have now investigated the association of po...

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Bibliographic Details
Published in:Current Opinion in Immunology 2001-10, Vol.13 (5), p.572-576
Main Authors: Akalin, Enver, Murphy, Barbara
Format: Article
Language:English
Subjects:
association
gene
Gene Expression Regulation - genetics
Gene Expression Regulation - immunology
Graft Rejection - genetics
Graft Rejection - immunology
Humans
Organ Transplantation - methods
polymorphism
Polymorphism, Genetic - genetics
Polymorphism, Genetic - immunology
transplantation
Transplantation Immunology - genetics
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Summary:The influence of gene polymorphisms in key immunoregulatory molecules on the clinical course post-transplant has become an area of active research, since it offers a possible explanation for the heterogeneity in outcomes between individuals. Several groups have now investigated the association of polymorphisms in molecules — including cytokines, cytokine receptors, adhesion molecules and costimulatory molecules — that participate in the immune response to an allograft. Several interesting observations have been made that would suggest that genetic variability influencing allograft survival reaches beyond that of the MHC molecules.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(00)00261-2