Hematologic masquerade of rhabdomyosarcoma

We present the case of a 12‐year‐old boy admitted with the diagnosis of acute leukemia, but found to have an infiltration of the marrow by an alveolar rhabdomyosarcoma (RMS) as determined by the cytogenetic demonstration of a t(2;13)(q25;q14). A primary tumor could not be found. With this case as a...

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Bibliographic Details
Published in:American journal of hematology 2001-09, Vol.68 (1), p.51-57
Main Authors: Sandberg, Avery A., Stone, John F., Czarnecki, Lawrence, Cohen, Jesse D.
Format: Article
Language:English
Subjects:
Acute Disease
acute leukemia
Biological and medical sciences
Bone Marrow - pathology
Child
Cytogenetic Analysis
Diagnosis, Differential
Diseases of striated muscles. Neuromuscular diseases
Hematologic and hematopoietic diseases
Humans
Leukemia - diagnosis
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lung Neoplasms - diagnosis
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Medical sciences
Neoplasm Invasiveness
Neoplasms, Unknown Primary
Neurology
Pulmonary Alveoli
rhabdomyosarcoma
Rhabdomyosarcoma - diagnosis
Rhabdomyosarcoma - genetics
Rhabdomyosarcoma - pathology
Translocation, Genetic
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Summary:We present the case of a 12‐year‐old boy admitted with the diagnosis of acute leukemia, but found to have an infiltration of the marrow by an alveolar rhabdomyosarcoma (RMS) as determined by the cytogenetic demonstration of a t(2;13)(q25;q14). A primary tumor could not be found. With this case as a basis, we have tabulated features of all similar cases in the literature and discuss the possible optimal approaches to establishing the correct diagnosis in such patients. Am. J. Hematol. 68:51–57, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.1148