Platelet Serotonergic Mechanisms in Patients with Cancer of the Urinary Bladder

Platelet reactivity of hypertensive patients and patients with cancer of the urinary bladder was examined in vitro in comparison with normotensive patients. A significant increase in free serotonin in the plasma of patients with cancer of the bladder and a less pronounced increase in hypertensive su...

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Bibliographic Details
Published in:Thrombosis research 2000-06, Vol.98 (5), p.367-374
Main Authors: Pawlak, Dariusz, Malczyk, Eugeniusz, Darewicz, Jan, Azzadin, Arsalan, Buczko, Wlodzimierz
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - pharmacology
Aged
Biological and medical sciences
Blood platelets
Blood Platelets - metabolism
Blood Platelets - physiology
Cancer of the urinary bladder
Collagen - pharmacology
Female
Humans
Hypertension - metabolism
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Pharmacokinetics
Platelet Aggregation - drug effects
Serotonin
Serotonin - blood
Serotonin - pharmacology
Serotonin - physiology
Thrombin - pharmacology
Tritium
Tumors of the urinary system
Urinary Bladder Neoplasms - metabolism
Urinary tract. Prostate gland
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Summary:Platelet reactivity of hypertensive patients and patients with cancer of the urinary bladder was examined in vitro in comparison with normotensive patients. A significant increase in free serotonin in the plasma of patients with cancer of the bladder and a less pronounced increase in hypertensive subjects was observed. The platelets in neoplastic disease and hypertension showed a significant reduction in the kinetics of serotonin uptake. However, the release reaction was markedly higher, compared with healthy volunteers. Enhancement of platelet aggregation with serotonin was much greater in patients with cancer of the bladder than in control groups and in hypertensive patients. These data indicate increased sensitivity to serotonin within the platelets of patients with cancer of the urinary bladder.
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(00)00198-5