Factors derived from adrenals are required for activation of cardiac gene expression in angiotensin II-induced hypertension

The mechanisms mediating the activation of cardiac gene expression during pressure overload are not fully understood. We examined whether angiotensin II-induced activation of ventricular gene expression is related to blood pressure and ventricular mass or requires other factors by infusing angiotens...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2001-10, Vol.142 (10), p.4256-4263
Main Authors: Földes, G, Suo, M, Szokodi, I, Lakó-Futó, Z, deChâtel, R, Vuolteenaho, O, Huttunen, P, Ruskoaho, H, Tóth, M
Format: Article
Language:English
Subjects:
Adrenal Glands - physiopathology
Angiotensin II
Animals
Gene Expression Regulation
Heart - physiopathology
Hypertension - genetics
Hypertension - physiopathology
Male
Rats
Rats, Sprague-Dawley
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Summary:The mechanisms mediating the activation of cardiac gene expression during pressure overload are not fully understood. We examined whether angiotensin II-induced activation of ventricular gene expression is related to blood pressure and ventricular mass or requires other factors by infusing angiotensin II in sham-operated and adrenalectomized rats. In sham-operated rats, angiotensin II (33 microg/kg x h, sc) produced a significant increase in mean arterial pressure (measured by telemetry) within 3 h. Mean arterial pressure (up to 45 h) and the increase in left ventricular hypertrophy in adrenalectomized rats during angiotensin II infusion were similar to those in sham-operated rats. Angiotensin II produced 3.6-fold (P < 0.01) and 20.4-fold (P < 0.001) increases in ventricular atrial natriuretic peptide mRNA levels at 12 and 72 h, respectively. Angiotensin II infusion for 12 h also significantly increased the ventricular mRNA levels of B-type natriuretic peptide (5.2-fold) and adrenomedullin (1.4-fold). Adrenalectomy either abolished (atrial natriuretic peptide and adrenomedullin) or blunted (B-type natriuretic peptide) the early activation of ventricular gene expression by angiotensin II. The baseline synthesis of atrial natriuretic peptide, B-type natriuretic peptide, and adrenomedullin in the ventricle remained unchanged in adrenalectomized rats. In conclusion, our results indicate that factors derived from the adrenals are required for angiotensin II-induced early activation of cardiac gene expression.
ISSN:0013-7227
DOI:10.1210/en.142.10.4256