Chemical synoviorthesis with osmic acid in haemophilia

Based on previous experience in inflammatory arthritis, a small number of open studies have evaluated the usefulness of chemical synoviorthesis with osmic acid in haemophilia, with various assessment criteria and a wide range of follow‐up periods. Based on these studies, the efficacy of osmic acid s...

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Bibliographic Details
Published in:Haemophilia : the official journal of the World Federation of Hemophilia 2001-07, Vol.7 (s2), p.20-25
Main Author: Ayral, X.
Format: Article
Language:English
Subjects:
Age Factors
cartilage
chemical synoviorthesis
haemophilia
Hemarthrosis - complications
Hemarthrosis - drug therapy
Hemarthrosis - etiology
Hemophilia A - complications
Hemophilia A - pathology
Hemophilia A - therapy
Humans
osmic acid
Osmium Tetroxide - therapeutic use
Radioisotopes - therapeutic use
rheumatoid arthritis
synovitis
Synovitis - drug therapy
Synovitis - etiology
Synovitis - pathology
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Summary:Based on previous experience in inflammatory arthritis, a small number of open studies have evaluated the usefulness of chemical synoviorthesis with osmic acid in haemophilia, with various assessment criteria and a wide range of follow‐up periods. Based on these studies, the efficacy of osmic acid seems modest, with 30–44% of good clinical and radiological results, but with fair or poor clinical results in other patients with a possible deleterious effect on cartilage. Osmic acid was found inferior to Yttrium‐90 in one retrospective study. Synoviorthesis with osmic acid seems particularly indicated in haemophilic arthritis with no or mild radiological deterioration in children between 8 and 15 years of age. However, prospective randomized studies are clearly required to evaluate the symptomatic and structural effects of chemical and radioactive synoviorthesis in haemophilic arthritis.
ISSN:1351-8216
1365-2516
DOI:10.1046/j.1365-2516.2001.00104.x