Various scoring systems evaluating histologic features of chronic hepatitis C treated with interferon

• Published in: Human pathology 2001-09, Vol.32 (9), p.910-917
• Main Authors: Ikawa, Hirotsugu, Hayashi, Yoshitake, Ninomiya, Toshiaki, Yano, Yoshihiko, Nakaji, Miyuki, Nagano, Hidenobu, Seo, Yasushi, Kumon, Yoshiko, Yoon, Seitetsu, Kasuga, Masato, Itoh, Hiroshi, Ohbayashi, Chiho
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antiviral Agents - therapeutic use; Biological and medical sciences; Biopsy; chronic hepatitis C; Disease Progression; False Positive Reactions; Female; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - pathology; histology; Human viral diseases; Humans; Infectious diseases; interferon therapy; Interferon-alpha - therapeutic use; Male; Medical sciences; Middle Aged; Pathology, Surgical - methods; Predictive Value of Tests; scoring system; Treatment Outcome; Viral diseases; Viral hepatitis
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1053/hupa.2001.27108

Various scoring systems for chronic hepatitis have been proposed; however, there is no standard scoring system for studies of interferon (IFN) therapy in patients with chronic hepatitis C. The aims of this study were to determine the most useful system reflecting histologic changes in biopsy specimens from complete responders and predicting the efficacy of IFN therapy. Patients with chronic hepatitis C were administered IFN-α for 6 months. Forty-six patients were included in this study and categorized as complete responders (n = 15), partial responders (n = 24), and nonresponders (n = 7) according to viral and biochemical responses to the therapy. Biopsy specimens obtained from each patient before and after treatment were evaluated under 3 different systems: Histological Activity Index (HAI), modified HAI, and Scheuer classification. Complete responders showed considerable improvement in both grade and stage on the modified HAI and Scheuer classifications. On the HAI, a considerable improvement was observed in grade but not in stage. No significant change was observed in partial responders or nonresponders on any system. Prediction of complete response was not possible under any system, but the pretreatment score reflecting piecemeal necrosis on any 1 of the 3 classifications and the fibrosis score on Scheuer classification were predictors of nonresponse. The modified HAI system and Scheuer classification were amply useful in evaluating histologic changes in complete responders. Scores higher than 4 of the categories reflecting piecemeal necrosis on any system and fibrosis scores of 3 or 4 on Scheuer classification predicted nonresponse to IFN therapy. HUM PATHOL 32:910-917. Copyright © 2001 by W.B. Saunders Company