Modulation of tight junction structure and function by cytokines

Dynamic regulation of tight junction function is fundamental to many physiologic processes. Disruption of tight junction function drastically alters paracellular permeability and is a hallmark of many pathologic states. Recently, an increasing number of cytokines have been shown to influence tight j...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2000-06, Vol.41 (3), p.303-313
Main Authors: Walsh, Shaun V, Hopkins, Ann M, Nusrat, Asma
Format: Article
Language:English
Subjects:
Actin
Animals
Cells
Cytokine
Cytokines - pharmacology
Epidermal Growth Factor - pharmacology
Hepatocyte Growth Factor - pharmacology
Humans
Interferon-gamma - pharmacology
Mechanical permeability
Proteins
Tight junction
Tight Junctions - chemistry
Tight Junctions - drug effects
Tight Junctions - physiology
Transforming Growth Factor beta - pharmacology
Tumor Necrosis Factor-alpha - pharmacology
ZO-1
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dynamic regulation of tight junction function is fundamental to many physiologic processes. Disruption of tight junction function drastically alters paracellular permeability and is a hallmark of many pathologic states. Recently, an increasing number of cytokines have been shown to influence tight junction function both in vitro and in vivo. Cytokine-induced effects on tight junction barrier function have also been correlated with effects on intrinsic tight junction proteins and the associated actin cytoskeleton. The aim of this article is to review studies relating to the effects of cytokines on tight junction function and structure.
ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(00)00048-X