Neural Cell Adhesion Molecule Expression in Adenoid Cystic Carcinoma of the Head and Neck

• Published in: The Laryngoscope 2000-06, Vol.110 (6), p.946-948
• Main Authors: Hutcheson, James A., Vural, Emre, Korourian, Sohelia, Hanna, Ehab
• Format: Article
• Language: English
• Subjects: adenoid cystic carcinoma; Adult; Aged; Aged, 80 and over; Antibodies, Anti-Idiotypic - immunology; Antibodies, Monoclonal - immunology; Biological and medical sciences; Carcinoma, Adenoid Cystic - immunology; Carcinoma, Adenoid Cystic - metabolism; Carcinoma, Adenoid Cystic - pathology; Female; head and neck; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Humans; Immunohistochemical methods; Immunohistochemistry; Immunological methods for diagnosis and exploration; Immunopathology; Male; Medical sciences; Middle Aged; Neural cell adhesion molecule; Neural Cell Adhesion Molecules - immunology; Neural Cell Adhesion Molecules - metabolism; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; perineural; Retrospective Studies; Tumors
• ISSN: 0023-852X; 1531-4995
• DOI: 10.1097/00005537-200006000-00011

Objective To investigate whether there is a correlation between neural cell adhesion molecule (NCAM) expression and perineural spread in patients with adenoid cystic carcinoma of the head and neck (ACCHN). Study Design Retrospective review of medical records and immunohistochemical staining of specimens from 37 patients treated at the University of Arkansas in Little Rock from 1987 to 1997. Methods Sections from paraffin‐embedded specimens were e‐amined for the presence of NCAM using monoclonal anti‐NCAM antibody by avidin‐biotin‐pero‐idase immunohistochemical staining. NCAM staining was scored in each specimen and correlated with the data obtained from patient charts. Results Twenty‐five of 37 specimens (68%) showed histopathological evidence of perineural spread. All 37 specimens (100%) stained positive for NCAM, regardless of perineural spread status. Conclusion Our results suggested that the use of NCAM expression as a predictor of perineural spread is highly unlikely.