A plant Shaker‐like K+ channel switches between two distinct gating modes resulting in either inward‐rectifying or ‘leak’ current

Among the Shaker‐like plant potassium channels, AKT2 is remarkable because it mediates both instantaneous ‘leak‐like’ and time‐dependent hyperpolarisation‐activated currents. This unique gating behaviour has been analysed in Xenopus oocytes and in COS and Chinese hamster ovary cells. Whole‐cell and...

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Bibliographic Details
Published in:FEBS letters 2001-09, Vol.505 (2), p.233-239
Main Authors: Dreyer, Ingo, Michard, Erwan, Lacombe, Benoı̂t, Thibaud, Jean-Baptiste
Format: Article
Language:English
Subjects:
Animals
Arabidopsis Proteins
CHO Cells
Cloning, Molecular
COS Cells
Cricetinae
DNA, Complementary - metabolism
Electrophysiology
Oocytes - metabolism
Patch-clamp
Phosphorylation
Plant Proteins - chemistry
Plant Proteins - metabolism
Post-translational modification
Potassium - metabolism
Potassium channel
Potassium Channels - chemistry
Potassium Channels - metabolism
Protein Processing, Post-Translational
Shaker Superfamily of Potassium Channels
Voltage-gating
Xenopus
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Summary:Among the Shaker‐like plant potassium channels, AKT2 is remarkable because it mediates both instantaneous ‘leak‐like’ and time‐dependent hyperpolarisation‐activated currents. This unique gating behaviour has been analysed in Xenopus oocytes and in COS and Chinese hamster ovary cells. Whole‐cell and single‐channel data show that (i) AKT2 channels display two distinct gating modes, (ii) the gating of a given AKT2 channel can change from one mode to the other and (iii) this conversion is under the control of post‐translational factor(s). This behaviour is strongly reminiscent of that of the KCNK2 channel, recently reported to be controlled by its phosphorylation state.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(01)02832-0