Identification of T-helper cell epitopes in the hypervariable region of the nucleocapsid (N) protein of rinderpest virus (RPV) in cattle

The proliferative responses to synthetic peptides by lymphocytes derived from rinderpest virus (RPV)-infected cattle, the natural host for RPV, were assayed by determining [ 3H]thymidine incorporation into the DNA. In eight out of twelve cattle tested, significant responses were detected to peptides...

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Bibliographic Details
Published in:Vaccine 2000-07, Vol.18 (27), p.3077-3081
Main Authors: Ohishi, Kazue, Kamata, Hiroshi, Yamanouchi, Kazuya, Barrett, Thomas
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Cattle
Epitopes, T-Lymphocyte
Fundamental and applied biological sciences. Psychology
Helper T-cell epitope
Immunization
Microbiology
Molecular Sequence Data
Nucleocapsid - immunology
Nucleocapsid protein
Peptide Fragments - immunology
Rinderpest virus
Rinderpest virus - immunology
T-Lymphocytes, Helper-Inducer - immunology
Thymidine - metabolism
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Virology
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Summary:The proliferative responses to synthetic peptides by lymphocytes derived from rinderpest virus (RPV)-infected cattle, the natural host for RPV, were assayed by determining [ 3H]thymidine incorporation into the DNA. In eight out of twelve cattle tested, significant responses were detected to peptides representing amino acids 452–501 in the C-terminal hypervariable region of the virus nucleocapsid (N) protein. It appears that helper T-cell epitope(s) for cattle which can be broadly recognized within an MHC diverse population, exists in this region of the protein.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(99)00538-1