Angiotensin II AT(1A) receptor antisense lowers blood pressure in acute 2-kidney, 1-clip hypertension

To test the effectiveness of antisense oligonucleotides targeted to the angiotensin type 1A (AT(1A)) receptor mRNA on blood pressure reduction, the 2-kidney, 1-clip (2K1C) Goldblatt model of hypertension was studied in the acute phase of hypertension, when the peripheral renin-angiotensin system is...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-09, Vol.38 (3 Pt 2), p.674-678
Main Authors: Galli, S M, Phillips, M I
Format: Article
Language:English
Subjects:
Acute Disease
Angiotensin II - metabolism
Animals
Autoradiography
Binding, Competitive
Blood Pressure - drug effects
Body Weight - drug effects
DNA, Antisense - pharmacokinetics
DNA, Antisense - pharmacology
DNA, Antisense - therapeutic use
Dose-Response Relationship, Drug
Hypertension, Renovascular - drug therapy
Hypertension, Renovascular - metabolism
Hypertension, Renovascular - physiopathology
Kidney Medulla - metabolism
Male
Rats
Rats, Sprague-Dawley
Receptor, Angiotensin, Type 1
Receptors, Angiotensin - genetics
Receptors, Angiotensin - metabolism
Sodium - urine
Time Factors
Tissue Distribution
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Summary:To test the effectiveness of antisense oligonucleotides targeted to the angiotensin type 1A (AT(1A)) receptor mRNA on blood pressure reduction, the 2-kidney, 1-clip (2K1C) Goldblatt model of hypertension was studied in the acute phase of hypertension, when the peripheral renin-angiotensin system is overactive. A single injection of AT(1A) receptor antisense oligodeoxynucleotides significantly reduced systolic blood pressure for a period of 8 days in 2K1C rats after clipping, from 157.5+/-5 mm Hg on day 7 to 141.3+/-3.0 mm Hg on day 15 after clipping (P
ISSN:0194-911X
1524-4563
DOI:10.1161/hy09t1.095207