Comparison of the contractile responses of human coronary bypass grafts and monkey arteries to human urotensin-II

Human urotensin‐II (hU‐II) is a cyclic peptide recently cloned in humans and present in human cardiac tissue and human arteries. The effects of hU‐II were studied on human coronary bypass grafts in vitro. In three out of eight human mammary arteries, and two out of three human radial arteries, hU‐II...

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Published in:Fundamental & clinical pharmacology 2001-08, Vol.15 (4), p.227-231
Main Authors: Paysant, J., Rupin, A., Simonet, S., Fabiani, J. N., Verbeuren, T. J.
Format: Article
Language:English
Subjects:
Aged
Animals
Arteries - drug effects
Arteries - physiology
Coronary Artery Bypass
Dose-Response Relationship, Drug
endothelium
Female
Humans
Macaca fascicularis
Male
Mammary Arteries - drug effects
Mammary Arteries - physiology
mammary artery
radial artery
Radial Artery - drug effects
Radial Artery - physiology
Rats
saphenous vein
Saphenous Vein - drug effects
Saphenous Vein - physiology
urotensin
Urotensins - pharmacology
Vasoconstriction - drug effects
Vasoconstriction - physiology
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Summary:Human urotensin‐II (hU‐II) is a cyclic peptide recently cloned in humans and present in human cardiac tissue and human arteries. The effects of hU‐II were studied on human coronary bypass grafts in vitro. In three out of eight human mammary arteries, and two out of three human radial arteries, hU‐II caused contraction; human saphenous veins did not respond to hU‐II. When it exists, the contraction slowly develops and has a low‐to‐moderate intensity. All radial arteries obtained from young healthy non‐human primates contracted strongly to hU‐II.
ISSN:0767-3981
1472-8206
DOI:10.1046/j.1472-8206.2001.00032.x