SYNTHESIS OF 2′,3′-DIDEOXY-2′,3′-DIDEHYDRO NUCLEOSIDES VIA A SERENDIPITOUS ROUTE

This paper describes a "green" synthesis of 2′,3′-unsaturated 2′,3′-dideoxynucl-eosides via an electrochemical reaction. Using this approach d4T, d4U, ddA and ddI can be synthesized in high yields.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2001-04, Vol.20 (4-7), p.1263-1266
Main Authors: Guo, Z., Sanghvi, Y. S., Brammer, L. E., Hudlicky, T.
Format: Article
Language:English
Subjects:
Dideoxynucleosides - chemical synthesis
Pyrimidine Nucleosides - chemical synthesis
Stereoisomerism
Thymidine - chemical synthesis
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Summary:This paper describes a "green" synthesis of 2′,3′-unsaturated 2′,3′-dideoxynucl-eosides via an electrochemical reaction. Using this approach d4T, d4U, ddA and ddI can be synthesized in high yields.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-100002532