Parallel array and mixture-based synthetic combinatorial chemistry: tools for the next millennium

Technological advances continue to be a central driving force in the acceleration of the drug discovery process. Combinatorial chemistry methods, developed over the past 15 years, represent a paradigm shift in drug discovery. Initially viewed as a curiosity by the pharmaceutical industry, combinator...

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Bibliographic Details
Published in:Annual review of pharmacology and toxicology 2000-01, Vol.40 (1), p.273-282
Main Author: Houghten, R A
Format: Article
Language:English
Subjects:
Combinatorial Chemistry Techniques
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Summary:Technological advances continue to be a central driving force in the acceleration of the drug discovery process. Combinatorial chemistry methods, developed over the past 15 years, represent a paradigm shift in drug discovery. Initially viewed as a curiosity by the pharmaceutical industry, combinatorial chemistry is now recognized as an essential tool that decreases the time of discovery and increases the throughput of chemical screening by as much as 1000-fold. The use of parallel array synthesis approaches and mixture-based combinatorial libraries for drug discovery is reviewed.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev.pharmtox.40.1.273