Chipping away at complex behavior: Transcriptome/phenotype correlations in the mouse brain

Highly parallel gene expression profiling has the potential to provide new insight into the molecular mechanisms of complex brain diseases and behavioral traits. We review how gene expression profiling in various brain regions of inbred mouse strains has been used to identify genes that may contribu...

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Bibliographic Details
Published in:Physiology & behavior 2001-08, Vol.73 (5), p.849-857
Main Authors: Carter, Todd A., Del Rio, Jo A., Greenhall, Jennifer A., Latronica, Mark L., Lockhart, David J., Barlow, Carrolee
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - physiology
Brain - physiology
DNA microarrays
Gene expression
Gene Expression - physiology
Inbred mouse strains
Mice
Mice, Inbred Strains - genetics
Motor Activity - physiology
Phenotype
Quantitative trait loci
Quantitative Trait, Heritable
Running
Transcription, Genetic - genetics
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Summary:Highly parallel gene expression profiling has the potential to provide new insight into the molecular mechanisms of complex brain diseases and behavioral traits. We review how gene expression profiling in various brain regions of inbred mouse strains has been used to identify genes that may contribute to strain-specific phenotypes. New data, which demonstrate the use of gene expression profiling in combination with behavioral testing to identify candidate genes involved in mediating variation in running wheel activity, are also presented. These and other studies suggest that a combination of gene expression profiling and more traditional genetic approaches, such as quantitative trait locus analysis, can be used to identify genes responsible for specific neurobehavioral phenotypes.
ISSN:0031-9384
1873-507X
DOI:10.1016/S0031-9384(01)00522-4