A novel multilocus genotyping assay to identify genetic predictors of stroke in sickle cell anaemia

We describe a novel multilocus genotyping assay permitting simultaneous identification of 60 candidate markers for stroke in sickle cell anaemia (SCA). Based on cerebral magnetic resonance imaging (MRI), 69 patients were divided into stroke and control groups. The variant allele, CBS 278thr, showed...

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Bibliographic Details
Published in:British journal of haematology 2001-09, Vol.114 (3), p.718-720
Main Authors: Hoppe, Carolyn, Cheng, Suzanne, Grow, Michael, Silbergleit, Arkadiy, Klitz, William, Trachtenberg, Elizabeth, Erlich, Henry, Vichinsky, Elliott, Styles, Lori
Format: Article
Language:English
Subjects:
Adolescent
Alleles
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - genetics
Anemias. Hemoglobinopathies
Apolipoproteins E - genetics
Biological and medical sciences
candidate genes
Case-Control Studies
Child
Cystathionine beta-Synthase - genetics
Diseases of red blood cells
Genetic Markers
genetic predictors
Genotype
Hematologic and hematopoietic diseases
Hematology
Humans
Medical sciences
Odds Ratio
Polymerase Chain Reaction - methods
polymorphisms
sickle cell anaemia
Sickle cell anemia
stroke
Stroke - etiology
Stroke - genetics
Tumor Necrosis Factor-alpha - genetics
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Summary:We describe a novel multilocus genotyping assay permitting simultaneous identification of 60 candidate markers for stroke in sickle cell anaemia (SCA). Based on cerebral magnetic resonance imaging (MRI), 69 patients were divided into stroke and control groups. The variant allele, CBS 278thr, showed protection from stroke, whereas the apoE3 allele showed a trend towards association with increased stroke risk. Several other variant alleles [TNFα (−308)A, CETP (−628)A, apoCIII (−641)A] showed a trend towards significant associations with stroke risk. These preliminary results on a small group of patients suggest that a multilocus genotyping assay may be valuable in identifying genes that increase the risk of stroke in SCA.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2001.02997.x