Downregulation of G protein-coupled receptors

Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated...

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Bibliographic Details
Published in:Current Opinion in Neurobiology 2000-06, Vol.10 (3), p.365-369
Main Authors: Tsao, Patricia, von Zastrow, Mark
Format: Article
Language:English
Subjects:
Animals
clathrin-coated pits
Desensitization
Down-Regulation - physiology
Downregulation
Endocytosis
Endocytosis - physiology
G protein
GTP-Binding Proteins - metabolism
Neurons - physiology
Plasticity
Receptor
Receptors, Cell Surface - metabolism
Regulation
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Summary:Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated pits followed by sorting to lysosomes, has been examined in detail. Specific protein interactions that control the specificity of G-protein-coupled receptor trafficking in this pathway are beginning to be elucidated.
ISSN:0959-4388
1873-6882
DOI:10.1016/S0959-4388(00)00096-9