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Downregulation of G protein-coupled receptors

Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated...

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Published in:	Current Opinion in Neurobiology 2000-06, Vol.10 (3), p.365-369
Main Authors:	Tsao, Patricia, von Zastrow, Mark
Format:	Article
Language:	English
Subjects:	Animals clathrin-coated pits Desensitization Down-Regulation - physiology Downregulation Endocytosis Endocytosis - physiology G protein GTP-Binding Proteins - metabolism Neurons - physiology Plasticity Receptor Receptors, Cell Surface - metabolism Regulation
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description	Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated pits followed by sorting to lysosomes, has been examined in detail. Specific protein interactions that control the specificity of G-protein-coupled receptor trafficking in this pathway are beginning to be elucidated.
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subjects	Animals clathrin-coated pits Desensitization Down-Regulation - physiology Downregulation Endocytosis Endocytosis - physiology G protein GTP-Binding Proteins - metabolism Neurons - physiology Plasticity Receptor Receptors, Cell Surface - metabolism Regulation
title	Downregulation of G protein-coupled receptors
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