Loading…
Chronic Plasmodium falciparum infections in an area of low intensity malaria transmission in the Sudan
Chronic Plasmodium falciparum malaria infections in a Sudanese village, in an area of seasonal and unstable malaria transmission, were monitored and genetically characterized to study the influence of persistent infection on the immunology and epidemiology of low endemicity malaria. During the Octob...
Saved in:
| Published in: | Parasitology 2000-05, Vol.120 (5), p.447-456 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c482t-25e4407b5a37db67e41396f5fea1b8e2dfb6b0217d60d7cda1ed147b1f87f57d3 |
|---|---|
| cites | |
| container_end_page | 456 |
| container_issue | 5 |
| container_start_page | 447 |
| container_title | Parasitology |
| container_volume | 120 |
| creator | HAMAD, A. A. EL HASSAN, I. M. EL KHALIFA, A. A. AHMED, G. I. ABDELRAHIM, S. A. THEANDER, T. G. ARNOT, D. E. |
| description | Chronic Plasmodium falciparum malaria infections in a Sudanese village, in an area of seasonal and unstable malaria
transmission, were monitored and genetically characterized to study the influence of persistent infection on the immunology
and epidemiology of low endemicity malaria. During the October–December malaria season of 1996, 51 individuals
out of a population of 420 had confirmed and treated P. falciparum malaria in the village of Daraweesh in eastern Sudan.
In a cross-sectional survey carried out in December 1996, an additional 6 individuals were found to harbour a microscopically
negative but polymerase chain reaction (PCR)-positive P. falciparum infection. On 1 January 1997, a cohort
of 43 individuals aged from 9 to 53, recruited from this group of recently malaria-infected individuals agreed to donate
fortnightly blood samples for the next 9 months, the first 6 of which constitute the long Sudanese dry season when
transmission falls to undetectable levels. Each blood sample was tested for the presence of persistent malaria infection by
microscopy and PCR. Parasite-positive samples were genotyped using PCR assays that detect allelic polymorphism at the
MSP-1, MSP-2 and GLURP marker gene loci. Of 43 individuals 16 were found to maintain chronic P. falciparum
infections which were continuously genetically characterized. |
| doi_str_mv | 10.1017/S0031182099005818 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71189878</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0031182099005818</cupid><sourcerecordid>17555897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-25e4407b5a37db67e41396f5fea1b8e2dfb6b0217d60d7cda1ed147b1f87f57d3</originalsourceid><addsrcrecordid>eNqFkduKFDEQhoMo7uzqA3gjfSHetaa6c-pLHdxZYcHD6HWozsHN2t0Zk2503940M6ggKARSpL6_qvIXIU-AvgAK8uWe0hZANbTrKOUK1D2yASa6WoGA-2Szpus1f0bOc76llIpWNA_JGVDFaCfZhvjtTYpTMNX7AfMYbVjGyuNgwgFTCcPknZlDnHIJKywnOayir4b4vbzMbsphvqtGHDAFrOaEUx5DzkWxCuYbV-0Xi9Mj8qBUze7x6b4gny_ffNpe1dfvdm-3r65rw1Qz1w13jFHZc2yl7YV0DNpOeO4dQq9cY30vetqAtIJaaSyCs8BkD15Jz6VtL8jzY91Dit8Wl2ddpjFuGHBycclaFrs6JdV_QZCcc9XJAsIRNCnmnJzXhxRGTHcaqF63oP_aQtE8PRVf-tHZPxRH2wvw7ARgNjj4YpsJ-TdXPk2btXd9xEKe3Y9faUxftZCt5FrsPujXlx_Zfrtjui18e5oVxz4F-8Xp27ikqTj-j2l_AoFerhs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17555897</pqid></control><display><type>article</type><title>Chronic Plasmodium falciparum infections in an area of low intensity malaria transmission in the Sudan</title><source>Cambridge University Press:Jisc Collections:Cambridge University Press Read and Publish Agreement 2021-24 (Reading list)</source><creator>HAMAD, A. A. ; EL HASSAN, I. M. ; EL KHALIFA, A. A. ; AHMED, G. I. ; ABDELRAHIM, S. A. ; THEANDER, T. G. ; ARNOT, D. E.</creator><creatorcontrib>HAMAD, A. A. ; EL HASSAN, I. M. ; EL KHALIFA, A. A. ; AHMED, G. I. ; ABDELRAHIM, S. A. ; THEANDER, T. G. ; ARNOT, D. E.</creatorcontrib><description>Chronic Plasmodium falciparum malaria infections in a Sudanese village, in an area of seasonal and unstable malaria
transmission, were monitored and genetically characterized to study the influence of persistent infection on the immunology
and epidemiology of low endemicity malaria. During the October–December malaria season of 1996, 51 individuals
out of a population of 420 had confirmed and treated P. falciparum malaria in the village of Daraweesh in eastern Sudan.
In a cross-sectional survey carried out in December 1996, an additional 6 individuals were found to harbour a microscopically
negative but polymerase chain reaction (PCR)-positive P. falciparum infection. On 1 January 1997, a cohort
of 43 individuals aged from 9 to 53, recruited from this group of recently malaria-infected individuals agreed to donate
fortnightly blood samples for the next 9 months, the first 6 of which constitute the long Sudanese dry season when
transmission falls to undetectable levels. Each blood sample was tested for the presence of persistent malaria infection by
microscopy and PCR. Parasite-positive samples were genotyped using PCR assays that detect allelic polymorphism at the
MSP-1, MSP-2 and GLURP marker gene loci. Of 43 individuals 16 were found to maintain chronic P. falciparum
infections which were continuously genetically characterized.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182099005818</identifier><identifier>PMID: 10840974</identifier><identifier>CODEN: PARAAE</identifier><language>eng</language><publisher>Cambridge: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Animals ; Biological and medical sciences ; Chronic Disease ; chronic infections ; Cross-Sectional Studies ; DNA, Protozoan - analysis ; Fever ; Human protozoal diseases ; Humans ; Infectious diseases ; Malaria ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Malaria, Falciparum - parasitology ; Malaria, Falciparum - transmission ; Medical sciences ; Middle Aged ; Parasitemia - parasitology ; Parasitic diseases ; Plasmodium falciparum ; Plasmodium falciparum - genetics ; Plasmodium falciparum - isolation & purification ; Polymerase Chain Reaction ; premunition ; Protozoal diseases ; Sudan ; Sudan - epidemiology ; Tropical medicine ; unstable malaria</subject><ispartof>Parasitology, 2000-05, Vol.120 (5), p.447-456</ispartof><rights>2000 Cambridge University Press</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-25e4407b5a37db67e41396f5fea1b8e2dfb6b0217d60d7cda1ed147b1f87f57d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182099005818/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,72960</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1396027$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10840974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAMAD, A. A.</creatorcontrib><creatorcontrib>EL HASSAN, I. M.</creatorcontrib><creatorcontrib>EL KHALIFA, A. A.</creatorcontrib><creatorcontrib>AHMED, G. I.</creatorcontrib><creatorcontrib>ABDELRAHIM, S. A.</creatorcontrib><creatorcontrib>THEANDER, T. G.</creatorcontrib><creatorcontrib>ARNOT, D. E.</creatorcontrib><title>Chronic Plasmodium falciparum infections in an area of low intensity malaria transmission in the Sudan</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>Chronic Plasmodium falciparum malaria infections in a Sudanese village, in an area of seasonal and unstable malaria
transmission, were monitored and genetically characterized to study the influence of persistent infection on the immunology
and epidemiology of low endemicity malaria. During the October–December malaria season of 1996, 51 individuals
out of a population of 420 had confirmed and treated P. falciparum malaria in the village of Daraweesh in eastern Sudan.
In a cross-sectional survey carried out in December 1996, an additional 6 individuals were found to harbour a microscopically
negative but polymerase chain reaction (PCR)-positive P. falciparum infection. On 1 January 1997, a cohort
of 43 individuals aged from 9 to 53, recruited from this group of recently malaria-infected individuals agreed to donate
fortnightly blood samples for the next 9 months, the first 6 of which constitute the long Sudanese dry season when
transmission falls to undetectable levels. Each blood sample was tested for the presence of persistent malaria infection by
microscopy and PCR. Parasite-positive samples were genotyped using PCR assays that detect allelic polymorphism at the
MSP-1, MSP-2 and GLURP marker gene loci. Of 43 individuals 16 were found to maintain chronic P. falciparum
infections which were continuously genetically characterized.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>chronic infections</subject><subject>Cross-Sectional Studies</subject><subject>DNA, Protozoan - analysis</subject><subject>Fever</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Malaria, Falciparum - transmission</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parasitemia - parasitology</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - genetics</subject><subject>Plasmodium falciparum - isolation & purification</subject><subject>Polymerase Chain Reaction</subject><subject>premunition</subject><subject>Protozoal diseases</subject><subject>Sudan</subject><subject>Sudan - epidemiology</subject><subject>Tropical medicine</subject><subject>unstable malaria</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkduKFDEQhoMo7uzqA3gjfSHetaa6c-pLHdxZYcHD6HWozsHN2t0Zk2503940M6ggKARSpL6_qvIXIU-AvgAK8uWe0hZANbTrKOUK1D2yASa6WoGA-2Szpus1f0bOc76llIpWNA_JGVDFaCfZhvjtTYpTMNX7AfMYbVjGyuNgwgFTCcPknZlDnHIJKywnOayir4b4vbzMbsphvqtGHDAFrOaEUx5DzkWxCuYbV-0Xi9Mj8qBUze7x6b4gny_ffNpe1dfvdm-3r65rw1Qz1w13jFHZc2yl7YV0DNpOeO4dQq9cY30vetqAtIJaaSyCs8BkD15Jz6VtL8jzY91Dit8Wl2ddpjFuGHBycclaFrs6JdV_QZCcc9XJAsIRNCnmnJzXhxRGTHcaqF63oP_aQtE8PRVf-tHZPxRH2wvw7ARgNjj4YpsJ-TdXPk2btXd9xEKe3Y9faUxftZCt5FrsPujXlx_Zfrtjui18e5oVxz4F-8Xp27ikqTj-j2l_AoFerhs</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>HAMAD, A. A.</creator><creator>EL HASSAN, I. M.</creator><creator>EL KHALIFA, A. A.</creator><creator>AHMED, G. I.</creator><creator>ABDELRAHIM, S. A.</creator><creator>THEANDER, T. G.</creator><creator>ARNOT, D. E.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20000501</creationdate><title>Chronic Plasmodium falciparum infections in an area of low intensity malaria transmission in the Sudan</title><author>HAMAD, A. A. ; EL HASSAN, I. M. ; EL KHALIFA, A. A. ; AHMED, G. I. ; ABDELRAHIM, S. A. ; THEANDER, T. G. ; ARNOT, D. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-25e4407b5a37db67e41396f5fea1b8e2dfb6b0217d60d7cda1ed147b1f87f57d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>chronic infections</topic><topic>Cross-Sectional Studies</topic><topic>DNA, Protozoan - analysis</topic><topic>Fever</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - epidemiology</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Malaria, Falciparum - transmission</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parasitemia - parasitology</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - genetics</topic><topic>Plasmodium falciparum - isolation & purification</topic><topic>Polymerase Chain Reaction</topic><topic>premunition</topic><topic>Protozoal diseases</topic><topic>Sudan</topic><topic>Sudan - epidemiology</topic><topic>Tropical medicine</topic><topic>unstable malaria</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAMAD, A. A.</creatorcontrib><creatorcontrib>EL HASSAN, I. M.</creatorcontrib><creatorcontrib>EL KHALIFA, A. A.</creatorcontrib><creatorcontrib>AHMED, G. I.</creatorcontrib><creatorcontrib>ABDELRAHIM, S. A.</creatorcontrib><creatorcontrib>THEANDER, T. G.</creatorcontrib><creatorcontrib>ARNOT, D. E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAMAD, A. A.</au><au>EL HASSAN, I. M.</au><au>EL KHALIFA, A. A.</au><au>AHMED, G. I.</au><au>ABDELRAHIM, S. A.</au><au>THEANDER, T. G.</au><au>ARNOT, D. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Plasmodium falciparum infections in an area of low intensity malaria transmission in the Sudan</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>120</volume><issue>5</issue><spage>447</spage><epage>456</epage><pages>447-456</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><coden>PARAAE</coden><abstract>Chronic Plasmodium falciparum malaria infections in a Sudanese village, in an area of seasonal and unstable malaria
transmission, were monitored and genetically characterized to study the influence of persistent infection on the immunology
and epidemiology of low endemicity malaria. During the October–December malaria season of 1996, 51 individuals
out of a population of 420 had confirmed and treated P. falciparum malaria in the village of Daraweesh in eastern Sudan.
In a cross-sectional survey carried out in December 1996, an additional 6 individuals were found to harbour a microscopically
negative but polymerase chain reaction (PCR)-positive P. falciparum infection. On 1 January 1997, a cohort
of 43 individuals aged from 9 to 53, recruited from this group of recently malaria-infected individuals agreed to donate
fortnightly blood samples for the next 9 months, the first 6 of which constitute the long Sudanese dry season when
transmission falls to undetectable levels. Each blood sample was tested for the presence of persistent malaria infection by
microscopy and PCR. Parasite-positive samples were genotyped using PCR assays that detect allelic polymorphism at the
MSP-1, MSP-2 and GLURP marker gene loci. Of 43 individuals 16 were found to maintain chronic P. falciparum
infections which were continuously genetically characterized.</abstract><cop>Cambridge</cop><pub>Cambridge University Press</pub><pmid>10840974</pmid><doi>10.1017/S0031182099005818</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-1820 |
| ispartof | Parasitology, 2000-05, Vol.120 (5), p.447-456 |
| issn | 0031-1820 1469-8161 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71189878 |
| source | Cambridge University Press:Jisc Collections:Cambridge University Press Read and Publish Agreement 2021-24 (Reading list) |
| subjects | Adolescent Adult Animals Biological and medical sciences Chronic Disease chronic infections Cross-Sectional Studies DNA, Protozoan - analysis Fever Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Malaria, Falciparum - transmission Medical sciences Middle Aged Parasitemia - parasitology Parasitic diseases Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - isolation & purification Polymerase Chain Reaction premunition Protozoal diseases Sudan Sudan - epidemiology Tropical medicine unstable malaria |
| title | Chronic Plasmodium falciparum infections in an area of low intensity malaria transmission in the Sudan |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T03%3A52%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20Plasmodium%20falciparum%20infections%20in%20an%20area%20of%20low%20intensity%20malaria%20transmission%20in%20the%20Sudan&rft.jtitle=Parasitology&rft.au=HAMAD,%20A.%20A.&rft.date=2000-05-01&rft.volume=120&rft.issue=5&rft.spage=447&rft.epage=456&rft.pages=447-456&rft.issn=0031-1820&rft.eissn=1469-8161&rft.coden=PARAAE&rft_id=info:doi/10.1017/S0031182099005818&rft_dat=%3Cproquest_cross%3E17555897%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c482t-25e4407b5a37db67e41396f5fea1b8e2dfb6b0217d60d7cda1ed147b1f87f57d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17555897&rft_id=info:pmid/10840974&rft_cupid=10_1017_S0031182099005818&rfr_iscdi=true |