Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats

• Published in: Lipids 2000-04, Vol.35 (4), p.427-435
• Main Authors: Kamal-Eldin, A, Frank, J, Razdan, A, Tengblad, S, Basu, S, Vessby, B
• Format: Article
• Language: English
• Subjects: Animals; Bioavailability; Body weight; Butylated Hydroxytoluene - pharmacology; Cholesterol; Cholesterol - blood; Cholesterol - metabolism; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Cholesterol, VLDL - blood; Coumaric Acids - pharmacology; Curcumin - pharmacology; Diet; diet-related diseases; Dioxoles - pharmacology; Fatty acids; Fatty Acids - metabolism; Feed conversion; human nutrition; Lignans - pharmacology; Lipids; Liver; Liver - metabolism; Low density lipoprotein; Lung - metabolism; Male; Nutrition; nutrition physiology; Phenols; Phenols - administration & dosage; Phenols - pharmacology; Polyunsaturated fatty acids; Rats; Rats, Sprague-Dawley; Vitamin E - blood; Vitamin E - metabolism
• ISSN: 0024-4201; 1558-9307
• DOI: 10.1007/s11745-000-541-y

The effects of the phenolic compounds butylated hydroxytoluene (BHT), sesamin (S), curcumin (CU), and ferulic acid (FA) on plasma, liver, and lung concentrations of α‐ and γ‐tocopherols (T), on plasma and liver cholesterol, and on the fatty acid composition of liver lipids were studied in male Sprague‐Dawley rats. Test compounds were given to rats ad libitum for 4 wk at 4 g/kg diet, in a diet low but adequate in vitamin E (36 mg/kg of γ‐T and 25 mg/kg of α‐T) and containing 2 g/kg of cholesterol. BHT significantly reduced feed intake (P