The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose

The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited gre...

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Bibliographic Details
Published in:International journal of pharmaceutics 2000-04, Vol.200 (1), p.67-72
Main Authors: Edge, Stephen, Steele, D.Fraser, Chen, Ansong, Tobyn, Michael J, Staniforth, John N
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cellulose - chemistry
Chemistry, Pharmaceutical
Drug Compounding
Excipients - chemistry
General pharmacology
Hardness
Lubrication
Mechanical property
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Powders
Silicified microcrystalline cellulose
Silicon Dioxide - chemistry
Strength
Tensile Strength
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Summary:The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited greater strength than those of microcrystalline cellulose. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater stiffness and required considerably more energy for tensile failure to occur. Comparison of the data with that obtained for a dry blend of silicon dioxide/microcrystalline cellulose suggested that the functionality benefits of silicification were not due to a simple composite material model.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(00)00343-4