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Accelerator mass spectrometry (AMS): recent experience of its use in a clinical study and the potential future of the technique

1. The technique of accelerator mass spectrometry (AMS) is outlined. 2. The use of AMS in an initial validation study in animals is outlined. As part of the validation of the technique, samples from the animal study were analysed by both liquid scintillation counting (LSC) and, following dilution, b...

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Bibliographic Details
Published in:Xenobiotica 2001, Vol.31 (8-9), p.619-632
Main Authors: Young, G., Ellis, W., Ayrton, J., Hussey, E., Adamkiewicz, B.
Format: Article
Language:English
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Summary:1. The technique of accelerator mass spectrometry (AMS) is outlined. 2. The use of AMS in an initial validation study in animals is outlined. As part of the validation of the technique, samples from the animal study were analysed by both liquid scintillation counting (LSC) and, following dilution, by AMS. The results were similar. 3. The use of AMS in support of a clinical study is described. Six healthy male human volunteers were administered 2.7mg [14
ISSN:0049-8254
1366-5928
DOI:10.1080/00498250110052724