Architecture and function of the gastroesophageal barrier in the piglet

We describe the anatomy and function of the gastroesophageal barrier in the piglet. Male piglets underwent dissection (N = 6) and gastroesophageal muscle layer histometry (N = 6). Sedated, nonintubated animals (N = 13) underwent four-probe perfusion esophageal manometry and the pressure profiles wer...

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Bibliographic Details
Published in:Digestive diseases and sciences 2001-09, Vol.46 (9), p.1899-1908
Main Authors: VICENTE, Yvone, DA ROCHA, Cecilia, JIAKANG YU, HERNANDEZ-PEREDO, Guillermo, MARTINEZ, Leopoldo, PEREZ-MIES, Belen, TOVAR, Juan A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Deglutition - physiology
Digestive system
Esophagogastric Junction - anatomy & histology
Esophagogastric Junction - physiology
Investigative techniques, diagnostic techniques (general aspects)
Male
Manometry
Medical sciences
Models, Animal
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Swine
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Summary:We describe the anatomy and function of the gastroesophageal barrier in the piglet. Male piglets underwent dissection (N = 6) and gastroesophageal muscle layer histometry (N = 6). Sedated, nonintubated animals (N = 13) underwent four-probe perfusion esophageal manometry and the pressure profiles were related to the muscular thickness in the four quadrants. Hiatal and gastroesophageal anatomy are similar to our own. The muscle is thicker at the point where the clasp (on the right side) and sling fibers (on the left) concentrate. The pressure profiles were axially and radially asymmetric in coincidence with the thickness variations of the corresponding muscle layers. Sphincteric pressure was recorded as a plateau, whereas diaphragmatic crural pressure appeared as phasic oscillations in synchrony with respiration. The sphincter relaxed upon deglutition. In conclusion, the gastroesophageal structure and physiology are so similar in men and piglets that piglets are excellent models for research in this area.
ISSN:0163-2116
1573-2568
DOI:10.1023/a:1010631030320