Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required?

It is becoming increasingly accepted that gene loci comprise an extensive cis-regulatory system that encodes different layers of regulatory information, all of which are necessary to achieve and maintain tissue-specific gene expression in ontogeny. To gain a detailed understanding of developmental p...

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Bibliographic Details
Published in:Trends in Genetics 2000-07, Vol.16 (7), p.310-315
Main Author: Bonifer, Constanze
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromatin structure
Cis-regulation
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation, Developmental - genetics
Genome
Humans
Locus control region
Molecular and cellular biology
Molecular genetics
Nucleosome structure
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Summary:It is becoming increasingly accepted that gene loci comprise an extensive cis-regulatory system that encodes different layers of regulatory information, all of which are necessary to achieve and maintain tissue-specific gene expression in ontogeny. To gain a detailed understanding of developmental processes, it is clearly necessary to unravel the molecular basis behind the different regulatory processes that control gene expression. This information is also of utmost importance for any practical application that uses gene transfer technology.
ISSN:0168-9525
DOI:10.1016/S0168-9525(00)02029-1