Is Blood Homocysteine Elevated in Migraine?

Objective.—To determine total serum homocysteine levels in a large group of patients with migraine with and without aura. Background.—Hypercoagulable state is a known risk factor for stroke in the young. The existence of a hypercoagulable state has been postulated in migraine and homocysteinemia wit...

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Bibliographic Details
Published in:Headache 2001-09, Vol.41 (8), p.779-781
Main Authors: Hering-Hanit, R., Gadoth, N., Yavetz, A., Gavendo, S., Sela, B.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Chromatography, High Pressure Liquid
Female
homocysteine
Homocysteine - blood
Humans
hypercoagulable
Male
Medical sciences
Middle Aged
migraine
Migraine Disorders - blood
Migraine Disorders - physiopathology
Neurology
stroke
Vascular diseases and vascular malformations of the nervous system
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Summary:Objective.—To determine total serum homocysteine levels in a large group of patients with migraine with and without aura. Background.—Hypercoagulable state is a known risk factor for stroke in the young. The existence of a hypercoagulable state has been postulated in migraine and homocysteinemia with young‐onset stroke. To the best of our knowledge, blood homocysteine has not been studied in a significant number of patients with various forms of migraine. Methods.—Total serum homocysteine was measured with high‐performance liquid chromatography in 78 patients with migraine and in 126 age‐ and sex‐matched healthy volunteers. Results.—Seventy‐eight patients aged 18 to 65 years were studied: 22 with migraine with aura and 56 with migraine without aura. Only 1 man had significantly elevated blood homocysteine (38.6 μmol/L), while another had a borderline elevation (15.8 μmol/L) (reference value for both sexes in our laboratory is 4 to 14 μmol/L). Both patients suffered from migraine without aura. Conclusions.—Blood homocysteine is not elevated in migraine.
ISSN:0017-8748
1526-4610
DOI:10.1046/j.1526-4610.2001.01143.x