Cardiovascular indices of peripheral and central sympathetic activation

A number of sympathetic nervous system (SNS) parameters have been used in cardiovascular psychophysiology. This study aimed to describe the pattern and redundancy of a set of SNS parameters during peripherally induced changes of cardiac sympathetic activation and reflex modulation of central SNS con...

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Bibliographic Details
Published in:Psychosomatic medicine 2001-09, Vol.63 (5), p.788-796
Main Authors: Schächinger, H, Weinbacher, M, Kiss, A, Ritz, R, Langewitz, W
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - administration & dosage
Adrenergic beta-Agonists - administration & dosage
Adrenergic beta-Antagonists - administration & dosage
Adult
Blood Pressure - drug effects
Cardiovascular Physiological Phenomena - drug effects
Cardiovascular System - drug effects
Cross-Over Studies
Epinephrine - administration & dosage
Heart Rate - drug effects
Humans
Male
Nitroprusside - administration & dosage
Norepinephrine - administration & dosage
Propanolamines - administration & dosage
Single-Blind Method
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiology
Vasodilator Agents - administration & dosage
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Summary:A number of sympathetic nervous system (SNS) parameters have been used in cardiovascular psychophysiology. This study aimed to describe the pattern and redundancy of a set of SNS parameters during peripherally induced changes of cardiac sympathetic activation and reflex modulation of central SNS control. Preejection period (PEP) was assessed as a marker of peripheral sympathetic activation. Low-frequency blood pressure variability (BPV) was assessed as an estimate of central SNS control. Peripheral beta-sympathetic stimulation and blockade were achieved with epinephrine and esmolol hydrochloride (beta1-blockade), respectively. Changes in central SNS output were induced by loading and unloading arterial baroreceptors with norepinephrine and nitroprusside sodium, respectively. This single-blinded, crossover study in 24 healthy men also included two placebo control periods. PEP was derived from impedance cardiography and adjusted individually for heart rate. BPV was calculated by power spectral analyses of beat-to-beat heart rate and systolic blood pressure (Finapres system) data. PEP decreased during epinephrine infusion (-40.1 +/- 3.8 ms, p
ISSN:0033-3174
DOI:10.1097/00006842-200109000-00012