Increased blood levels of platelet‐activating factor in insulin‐dependent diabetic patients with microalbuminuria

Background. Platelet‐activating factor (PAF), a phospholipid mediator of inflammation, may induce an enhanced size‐ and charge‐dependent glomerular permeability in experimental animals. Studies on the role of PAF in enhanced glomerular permeability in the early phase of diabetic nephropathy are stil...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2000-07, Vol.15 (7), p.994-999
Main Authors: Cavallo‐Perin, Paolo, Lupia, Enrico, Gruden, Gabriella, Olivetti, Carla, De Martino, Antonella, Cassader, Maurizio, Furlani, Daniela, Servillo, Luigi, Quagliuolo, Lucro, Iorio, Eugenio, Boccellino, Marcia Rosario, Montrucchio, Guiseppe, Camussi, Giovanni
Format: Article
Language:English
Subjects:
1-Alkyl-2-acetylglycerophosphocholine Esterase
Adult
Albuminuria - blood
Associated diseases and complications
Biological and medical sciences
diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
exercise
Female
Humans
Male
Medical sciences
microalbuminuria
PAF
Phospholipases A - blood
Platelet Activating Factor - analysis
Reference Values
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Summary:Background. Platelet‐activating factor (PAF), a phospholipid mediator of inflammation, may induce an enhanced size‐ and charge‐dependent glomerular permeability in experimental animals. Studies on the role of PAF in enhanced glomerular permeability in the early phase of diabetic nephropathy are still lacking. Methods. We evaluated the intravascular levels of PAF and its main catabolic enzyme, the PAF‐specific plasma acetyl‐hydrolase (PAF‐AH), in basal conditions and after exercise, in normo‐ or micro‐albuminuric insulin‐dependent diabetic (IDD) patients and in normal subjects. Results. The results obtained indicate that the concentration of PAF in whole blood was significantly enhanced in basal conditions, during and after exercise in all microalbuminuric IDD patients, but not in normoalbuminuric IDD or in control subjects. The increased concentration of PAF did not correlate with changes in the activity of PAF‐AH, suggesting an enhanced production rather than a decreased catabolism of PAF. Conclusions. These results indicate an association between increased production of PAF and enhanced glomerular permeability in microalbuminuric IDD patients.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/15.7.994