Clinical and histopathological features of colonic stromal tumor in a child

Neoplasms of the colonic submucosa are rare in children. Gastrointestinal stromal tumors (GISTs) are undifferentiated tumors, usually diagnosed by immunohistochemistry. We report a 4-year-old girl with a submucosal GIST of the ascending colon, which was detected by computed tomography. Diagnosis aft...

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Bibliographic Details
Published in:Journal of gastroenterology 2000, Vol.35 (6), p.456-459
Main Authors: Terada, R, Ito, S, Akama, F, Kidogawa, H, Ichikawa, K, Ooe, H
Format: Article
Language:English
Subjects:
Child, Preschool
Colon - pathology
Colonic Neoplasms - epidemiology
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Female
Humans
Immunohistochemistry
Mesenchymoma - epidemiology
Mesenchymoma - metabolism
Mesenchymoma - pathology
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Summary:Neoplasms of the colonic submucosa are rare in children. Gastrointestinal stromal tumors (GISTs) are undifferentiated tumors, usually diagnosed by immunohistochemistry. We report a 4-year-old girl with a submucosal GIST of the ascending colon, which was detected by computed tomography. Diagnosis after ileocecal resection was established by histology. In addition, sections were examined immunohistochemically, using antibodies against vimentin, desmin, alpha-smooth muscle actin, S100, neuron-specific enolase, c-kit, and CD34. Hematoxylin and eosin-stained sections showed interlacing fascicles with occasional palisades of epithelioid and spindle cells. The tumor cells were positive for vimentin and CD34. To our knowledge, this is the first reported case of colonic stromal tumor in a child.
ISSN:0944-1174
DOI:10.1007/PL00009984