Oxacillin susceptibility testing of Staphylococcus saprophyticus using disk diffusion, agar dilution, broth microdilution, and the Vitek GPS-105 card

Eighty-three mecA negative isolates of S. saprophyticus had oxacillin zone diameters ≤ 15 mm or MICs ranging from ≤ 0.25–1.0 μg/ml when tested by either agar dilution, broth microdilution, or the Vitek GPS-105 card. Greater than 90% of these isolates would be considered resistant using NCCLS M7-A5,...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2001-08, Vol.40 (4), p.203-205
Main Authors: Ramotar, Karam, Woods, Wendi, Toye, Baldwin
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins
Bacteriological methods and techniques used in bacteriology
Bacteriology
Biological and medical sciences
Culture Media
Fundamental and applied biological sciences. Psychology
Medical sciences
Microbial Sensitivity Tests - methods
Microbial Sensitivity Tests - standards
Microbiology
Oxacillin - pharmacology
Penicillin Resistance
Penicillins - pharmacology
Pharmacology. Drug treatments
Staphylococcus - drug effects
Staphylococcus - enzymology
Staphylococcus - genetics
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Summary:Eighty-three mecA negative isolates of S. saprophyticus had oxacillin zone diameters ≤ 15 mm or MICs ranging from ≤ 0.25–1.0 μg/ml when tested by either agar dilution, broth microdilution, or the Vitek GPS-105 card. Greater than 90% of these isolates would be considered resistant using NCCLS M7-A5, M100-S10 criteria. These results suggest that the current NCCLS MIC and zone diameter breakpoints for oxacillin resistance in coagulase-negative Staphylococci are not appropriate for S. saprophyticus as they do not correlate with the presence of the mecA gene.
ISSN:0732-8893
1879-0070
DOI:10.1016/S0732-8893(01)00268-1