Co‐existence of cutaneous T‐cell lymphoma and B hairy cell leukemia

• Published in: American journal of hematology 2000-07, Vol.64 (3), p.197-202
• Main Authors: Paolini, Rossella, Poletti, Alessandro, Ramazzina, Emilio, Menin, Chiara, Santacatterina, Maria, Montagna, Marco, Bonaldi, Laura, Del Mistro, Annarosa, Zamboni, Sergio, D'Andrea, Emma
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Biopsy; Blotting, Southern; Bone Marrow - pathology; DNA - blood; Female; hairy cell leukemia; Hematologic and hematopoietic diseases; Humans; Immunophenotyping; Leukemia, B-Cell - complications; Leukemia, Hairy Cell - complications; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, T-Cell, Cutaneous - complications; Medical sciences; peripheral T‐cell lymphoma; semi‐nested PCR; Skin - pathology; Skin Neoplasms - complications; Southern blot analysis
• ISSN: 0361-8609; 1096-8652
• DOI: 10.1002/1096-8652(200007)64:3<197::AID-AJH10>3.0.CO;2-F

A primary cutaneous form of peripheral T‐cell lymphoma (PTCL) and a low grade B‐cell non‐Hodgkin's lymphoma that was classified as a variant of hairy cell leukemia (HCL) were simultaneously diagnosed in a 79‐year‐old woman by both phenotypic and genotypic analyses. The coexistence of a T‐ and B‐cell lymphoma in the same patient is rare, and, to our knowledge, this particular association has not been previously described. The patient was referred to our Department for evaluation of multiple cutaneous itchy, reddish plaques; laboratory analyses disclosed a lymphocytosis, that presented 6 years earlier. A bone marrow aspirate showed a 50% B‐cell interstitial infiltrate, while a skin biopsy surprisingly revealed a PTCL. Clonality of both neoplastic processes was assessed by Southern blot analysis. The indolent clinical course of the cutaneous disease, and the low and stable number of circulating neoplastic T cells supported the diagnosis of a mycosis fungoides (MF)‐like PTCL. Possible oncogenic events and/or putative underlying viral infections which could have played a role in the occurrence of B‐ and T‐cell non‐Hodgkin's lymphomas in the same patient are discussed. Am. J. Hematol. 64:197–202, 2000. © 2000 Wiley‐Liss, Inc.