Synthesis and structure-activity relationships of quaternary ammonium cephalosporins with 3-pyrazolylpyridinium derivatives

Cephalosporins with 3-pyazolylpyridinium at C-3 position, which is supposed to exhibit synergic activity of ceftazidime and cefoselis, were synthesized and their antibacterial activity against gram-positive and gram-negative was inspected.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2000-06, Vol.10 (11), p.1211-1214
Main Authors: KWAN YOUNG CHANG, SUNG HOON KIM, NAM, G, JAE HONG SEO, JOONG HYUP KIM, HA, D.-C
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cephalosporins - chemical synthesis
Cephalosporins - chemistry
Cephalosporins - pharmacology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Pyridinium Compounds - chemistry
Quaternary Ammonium Compounds - chemistry
Structure-Activity Relationship
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Description
Summary:Cephalosporins with 3-pyazolylpyridinium at C-3 position, which is supposed to exhibit synergic activity of ceftazidime and cefoselis, were synthesized and their antibacterial activity against gram-positive and gram-negative was inspected.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00203-1