Influence of clinical history on airways bacterial colonization in subjects with chronic tracheostomy

Patients with chronic tracheostomy are subject to significant bacterial colonization of the airways, a risk factor for respiratory infections. The aim of our study was to verify whether bacterial colonization and humoral immune response in the airways can be influenced by the disease which led to ch...

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Bibliographic Details
Published in:Respiratory medicine 2000-05, Vol.94 (5), p.436-440
Main Authors: LUSUARDI, M., CAPELLI, A., CERUTTI, C.G., GNEMMI, I., ZACCARIA, S., DONNER, C.F.
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Bacterial - analysis
bacteriology
bronchial aspirate
Chronic Disease
chronic obstructive pulmonary disease
chronic tracheostomy
Female
Humans
immunoglobulins
kyphoscoliosis
Lung Diseases, Obstructive - complications
Lung Diseases, Obstructive - surgery
Male
Middle Aged
neuromuscular disorders
Pseudomonas - immunology
Pseudomonas aeruginosa - immunology
Respiratory Insufficiency - complications
Respiratory Insufficiency - surgery
Respiratory Tract Infections - etiology
Serratia marcescens - immunology
Staphylococcus aureus - immunology
Tracheostomy - adverse effects
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Summary:Patients with chronic tracheostomy are subject to significant bacterial colonization of the airways, a risk factor for respiratory infections. The aim of our study was to verify whether bacterial colonization and humoral immune response in the airways can be influenced by the disease which led to chronic respiratory failure and tracheostomy. Thirty-nine clinically stable outpatients with chronic tracheostomy were considered: 24 were affected by chronic obstructive pulmonary disease (COPD) (mean age 66 years, range 54–78, M/F 19/3; months since tracheostomy 23, range 3–62), 15 by restrictive lung disease (RLD) (12 thoracic wall deformities, three neuromuscular disease; age 57 years, range 41–72; M/F 3/12, months since tracheostomy 22, range 2–68). Recent antibiotic or corticosteroid treatments (
ISSN:0954-6111
1532-3064
DOI:10.1053/rmed.1999.0761