Basal and day 12 inhibin concentrations in the prediction of ovarian response to gonadotrophins in women with PCOS

• Published in: Human reproduction (Oxford) 2001-10, Vol.16 (10), p.2079-2083
• Main Authors: Gökyar, Devran, Kökçü, Arif, Yanik, Filiz, Çetinkaya, Mehmet B., Alper, Tayfun, Malatyalioğlu, Erdal
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Dose-Response Relationship, Drug; Female; Female genital diseases; gonadotrophin; Gonadotropins - administration & dosage; Gonadotropins - therapeutic use; Gynecology. Andrology. Obstetrics; Humans; inhibins; Inhibins - blood; Medical sciences; Menstrual Cycle - blood; ovarian stimulation; Ovary - drug effects; Ovulation; Ovulation Induction; PCOS; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - drug therapy; Polycystic Ovary Syndrome - physiopathology; Predictive Value of Tests; Treatment Outcome; Tumors
• ISSN: 0268-1161; 1460-2350
• DOI: 10.1093/humrep/16.10.2079

BACKGROUND: In this study, we aimed to investigate whether basal and day 12 serum total inhibin concentrations in women with polycystic ovarian syndrome (PCOS) were of predictive value for the estimation of the ovarian response to gonadotrophins. METHODS: Ovulation induction with a very low dose gonadotrophin protocol, starting with 37.5 IU/day, was performed for 40 cycles on 35 patients with PCOS. Day 3 (basal) serum total inhibin, FSH and oestradiol concentrations; day 12 dominant follicle diameter, inhibin and oestradiol concentrations and midluteal serum progesterone concentrations were measured during the 40 cycles. The correlations between basal and day 12 inhibin concentrations and some critical ovulation monitoring parameters were investigated. RESULTS: Ovulation was obtained in 14 out of 40 cycles: 21% of cycles with basal inhibin