Antioxidant Effects of Calcium Antagonists in Rat Brain Homogenates

We studied the antioxidant activities of calcium antagonists against autoxidation in rat brain homogenates.The homogenates were incubated for 30 min at 37°C with or without a calcium antagonist and subsequently assayed for lipid peroxide content. Percent inhibition of the lipid peroxidation was used...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2000/06/01, Vol.23(6), pp.766-769
Main Authors: YAO, Kozo, INA, Yazuhiro, NAGASHIMA, Ken, OHMORI, Kenji, OHNO, Tetsuji
Format: Article
Language:English
Subjects:
Animals
antioxidant effect
Antioxidants - pharmacology
Biological and medical sciences
Brain - drug effects
Brain - metabolism
calcium antagonist
Calcium Channel Blockers - pharmacology
lipid peroxidation
Lipid Peroxidation - drug effects
Male
Medical sciences
Neuropharmacology
Neuroprotective agent
Pharmacology. Drug treatments
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:We studied the antioxidant activities of calcium antagonists against autoxidation in rat brain homogenates.The homogenates were incubated for 30 min at 37°C with or without a calcium antagonist and subsequently assayed for lipid peroxide content. Percent inhibition of the lipid peroxidation was used as an index of the antioxidant effect. Dihydropyridine calcium antagonists exhibited concentration-dependent (3-300 μmol/l) inhibitory effects against lipid peroxidation. The relative order of antioxidant potency and associated IC50 values (μmol/l) of the calcium antagonists for inhibition of the lipid peroxidation were as follows : nifedipine (51.5)>barnidipine(58.6)>benidipine (71.2)>nicardipine (129.3)>amlodipine (135.5)>nilvadipine (167.3)>nitrendipine (252.1)>>diltiazem (>300)=verapamil (>300). These results suggest that some dihydropyridine calcium antagonists show antioxidant properties. The antioxidant effects of the calcium antagonists may contribute to their pharmacological actions.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.23.766